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AuthorReale, Carla
AuthorIervolino, Anna
AuthorScudiero, Ivan
AuthorFerravante, Angela
AuthorEgildo D, Luca
AuthorMazzone, Pellegrino
AuthorZotti, Tiziana
AuthorLeonardi, Antonio
AuthorRoberto, Luca
AuthorZannini, Mariastella
AuthorCristofaro, Tiziana de
AuthorShanmugakona, Muralitharan
AuthorCapasso, Giovambattista
AuthorPasparakis, Manolis
AuthorVito, Pasquale
AuthorStilo, Romania
Available date2017-03-01T06:50:19Z
Publication Date2016-03-11
Publication NameJournal of Biological Chemistry
Identifierhttp://dx.doi.org/10.1074/jbc.M115.711697
CitationManolis Pasparakis, Pasquale Vito and Romania Stilo Zannini, Tiziana De Cristofaro, Muralitharan Shanmugakonar, Giovambattista Capasso, Pellegrino Mazzone, Tiziana Zotti, Antonio Leonardi, Luca Roberto, Mariastella Carla Reale, Anna Iervolino, Ivan Scudiero, Angela Ferravante, Luca Egildo D'Andrea, NF-kB Essential MOdulator (NEMO) Is Critical for Thyroid Function J. Biol. Chem. published online January 19, 2016
ISSN0021-9258
URIhttp://hdl.handle.net/10576/5323
AbstractThe I-κB kinase (IKK) subunit NEMO/IKKγ (NEMO) is an adapter molecule that is critical for canonical activation of NF-κB, a pleiotropic transcription factor controlling immunity, differentiation, cell growth, tumorigenesis and apoptosis. To explore the functional role of canonical NF-κB signaling in thyroid gland differentiation and function, we have generated a murine strain bearing a genetic deletion of the NEMO locus in thyroid. Here we show that thyrocyte-specific NEMO knockout mice gradually develop hypothyroidism after birth, which leads to reduced body weight and shortened life span. Histological and molecular analysis indicate that absence of NEMO in thyrocytes results in a dramatic loss of the thyroid gland cellularity, associated with down-regulation of thyroid differentiation markers and ongoing apoptosis. Thus, NEMO-dependent signaling is essential for normal thyroid physiology.
Languageen
PublisherAmerican Society for Biochemistry and Molecular Biology
SubjectNF-kappaB (NF-κB)
NEMO, thyroid
transgenic mice
knockout
thyroid hormone
apoptosis
TitleNF-κB Essential MOdulator (NEMO) Is Critical for Thyroid Function
TypeArticle
Pagination5765-5773
ESSN1083-351X
dc.accessType Open Access


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