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المؤلفSokary, Sara
المؤلفAlmaghrbi, Heba
المؤلفBawadi, Hiba
تاريخ الإتاحة2024-04-25T06:20:13Z
تاريخ النشر2024
اسم المنشورDiabetes, Metabolic Syndrome and Obesity
المصدرScopus
الرقم المعياري الدولي للكتاب11787007
معرّف المصادر الموحدhttp://dx.doi.org/10.2147/DMSO.S452660
معرّف المصادر الموحدhttp://hdl.handle.net/10576/54239
الملخصBackground: The escalating global obesity epidemic and the emergence of personalized medicine strategies point to the pressing need to investigate the interplay between genetic risk scores (GRSs), dietary intake, and their combined impact on weight status. This systematic review synthesizes evidence from diverse studies to elucidate how dietary patterns and individual foods interact with genetic predisposition to obesity. Methods: Literature searches were conducted in the PubMed, Embase, Science Direct, and Scopus databases until August 2023, following PRISMA guidelines. Out of 575 articles, 15 articles examining the interaction between genetic risk score for body mass index and dietary intake on weight outcomes met the inclusion criteria. All included studies were cross-sectional in design and were assessed for quality using the Newcastle-Ottawa Scale. Results: Unhealthy dietary intake exacerbated the genetic predisposition to obesity, evident in studies assessing Western diet, sulfur microbial diet, and individual macronutrients, including saturated fatty acids, sugar-sweetened beverages and fried foods. Conversely, adhering to healthier dietary intake mitigated the genetic predisposition to obesity, as observed in studies involving Alternative Healthy Eating Index, Alternative Mediterranean Diet, Dietary Approach to Stop Hypertension scores, healthy plant-based diets, and specific foods such as fruits, vegetables, and n-3 polyunsaturated fatty acids. Conclusion: This is the first systematic review to explore the interaction between genetics and dietary intake in shaping obesity outcomes. The findings have implications for tailored interventions; however, more controlled clinical trials with robust designs are needed to be able to recommend personalized nutrition based on nutrition for obesity prevention and management.
راعي المشروعWe would like to thank Qatar University as the APC fund was provided with the Qatar University grant: QUST-1-CHS-2024-1676.
اللغةen
الناشرDove Medical Press Ltd
الموضوعBody Mass Index
Dietary Intake
Genetic Risk Score
Systematic Review
Weight Status
العنوانThe Interaction Between Body Mass Index Genetic Risk Score and Dietary Intake on Weight Status: A Systematic Review
النوعArticle Review
الصفحات925-941
رقم المجلد17
dc.accessType Open Access


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