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AuthorAlsalahi, Abdulsamad
AuthorMaarof, Nian N.N.
AuthorAlshawsh, Mohammed A.
AuthorAljaberi, Musheer A.
AuthorQasem, Mousa A.
AuthorMahuob, Abdulaleem
AuthorBadroon, Nassrin A.
AuthorMussa, Ebthag A.M.
AuthorHamat, Rukman A.
AuthorAbdallah, Atiyah M.
Available date2024-04-30T06:16:30Z
Publication Date2024
Publication NameHeliyon
ResourceScopus
Identifierhttp://dx.doi.org/10.1016/j.heliyon.2024.e27390
ISSN24058440
URIhttp://hdl.handle.net/10576/54480
AbstractThe immune-modulatory effects of black seeds (Nigella sativa seeds, NSS) are well documented, but the overall in vivo impact of this important natural medicinal product on immune system function has yet to be established. Here we systematically reviewed and meta-analyzed the effects of NSS on humoral [serum titers of immunoglobulins including IgG, IgM, anti-Newcastle virus disease (anti-NDV), and sheep red blood cell antigen (anti-SRBC)] and cellular immunity [total white blood cell (WBC) count and percentages of monocytes, lymphocytes, basophils, neutrophils, and eosinophils] in healthy animals. The PubMed, ScienceDirect, Web of Science, and Scopus databases were searched according to predefined eligibility criteria. Meta-analyses were performed to estimate the final effect size using RevMan software. Seventeen animal studies were eligible for analysis. For humoral immunity, the overall pooled effect size (ES) of NSS on serum titers of IgM and anti-NVD antibodies was not significantly different [mean difference (MD) 75.27, 95% CI: −44.76 to 195.30, p = 0.22 (I2 = 89%, p = 0.003), and −0.01, 95% CI: −0.27 to 0.25, p = 0.94 (I2 = 74%, p = 0.02), respectively]. However, NSS significantly increased serum titers of IgG and anti-SRBC antibodies [MD 3.30, 95% CI: 2.27 to 4.32, p = 0.00001 (I2 = 0%, p = 0.97), and 1.15, 95% CI: 0.74 to 1.56, p = 0.00001 (I2 = 0%, p = 0.43), respectively]. For cellular immunity, the ES of NSS on WBCs, monocytes, and lymphocytes were not significantly different [MD 0.29, 95% CI: −0.55 to 1.13, p = 0.50, (I2 = 14%, p = 0.32), - 0.01, 95% CI: −0.45 to 0.44, p = 0.97 (I2 = 0%, p = 0.77), and 4.73, 95% CI: −7.13 to 16.59, p = 0.43, (I2 = 99%, p = 0.00001), respectively]. In conclusion, black seeds enhance humoral immunity in healthy animals but do not affect cellular immunity.
Languageen
PublisherElsevier Ltd
SubjectBlack cumin
Black seeds
Cellular
Humeral
Immunity
Meta-analysis
Nigella sativa
Thymoquinone
TitleImmune stimulatory effect of Nigella sativa in healthy animal models: A systematic review and meta-analysis
TypeArticle
Issue Number6
Volume Number10
dc.accessType Open Access


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