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AuthorAlzu'bi, Ayman
AuthorBaker, Worood Bani
AuthorAl-Trad, Bahaa
AuthorZoubi, Mazhar Salim Al
AuthorAbuAlArjah, Manal Isam
AuthorAbu-El-Rub, Ejlal
AuthorTahat, Lena
AuthorHelaly, Ahmed MNZ
AuthorGhorab, Doaa S.
AuthorEl-Huneidi, Waseem
AuthorAl-Zoubi, Raed M.
Available date2024-05-19T11:23:06Z
Publication Date2024
Publication NameBrain Research Bulletin
ResourceScopus
Identifierhttp://dx.doi.org/10.1016/j.brainresbull.2024.110917
ISSN3619230
URIhttp://hdl.handle.net/10576/55106
AbstractPurpose: Fentanyl, a fully synthetic opioid, is widely used for severe pain management and has a huge abuse potential for its psychostimulant effects. Unlike other opioids, the neurotoxic effects of chronic fentanyl administration are still unclear. In particular, little is known about its effect on the cerebral cortex. The current study aims to test the chronic toxicity of fentanyl in the mice model. Methods: Adult male Balb/c mice were chronically treated with low (0.05 mg/kg, i.p) and high (0.1 mg/kg, i.p) doses of fentanyl for 5 consecutive weeks, and various neurotoxic parameters, including apoptosis, oxidative stress, and neuroinflammatory response were assessed in the cortex. Potential histological as well as neurochemical changes were also evaluated. Results: The results of this study show that chronic fentanyl administration induced intense levels of apoptosis, oxidative stress, and neuroinflammation in the cerebral cortex. These findings were found to be correlated with histopathological characteristics of neural degeneration and white matter injury. Moreover, fentanyl administration was found to reduce the expression of both NMDA receptor subunits and dopamine receptors and elevate the level of epidermal growth factor (EGF). Conclusion: Fentanyl administration induced neurotoxic effects in the mouse cerebral cortex that could be primarily mediated by the evoked oxidative-inflammatory response. The altered expression of NMDA receptors, dopamine receptors, and EGF suggests the pernicious effects of fentanyl addiction that may end in the development of toxic psychosis.
SponsorThis study is funded by a grant from the Deanship of Scientific Research, Yarmouk University , Jordan (Grant # 29/2021 ). Open access of this article is generously funded by Qatar National Library (QNL).
Languageen
PublisherElsevier
SubjectApoptosis
Fentanyl
Neuroinflammation
Neurotoxicity
Oxidative Stress
TitleThe impact of chronic fentanyl administration on the cerebral cortex in mice: Molecular and histological effects
TypeArticle
Volume Number209
dc.accessType Open Access


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