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المؤلفNasser M., Rizk
المؤلفDerbala, Moutaz F.
تاريخ الإتاحة2024-05-22T10:00:00Z
تاريخ النشر2013-06
اسم المنشورClinics and Research in Hepatology and Gastroenterology
المعرّفhttp://dx.doi.org/10.1016/j.clinre.2012.09.012
الاقتباسRizk, N. M., & Derbala, M. F. (2013). Genetic polymorphisms of ICAM 1 and IL28 as predictors of liver fibrosis severity and viral clearance in hepatitis C genotype 4. Clinics and research in hepatology and gastroenterology, 37(3), 262-268.
الرقم المعياري الدولي للكتاب2210-7401
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S2210740112002598
معرّف المصادر الموحدhttp://hdl.handle.net/10576/55291
الملخصBackground and objectivesIntercellular adhesion molecule-1 (ICAM-1) is located on chromosome 19p13.2, and this protein plays an important role in the pathogenesis of the hepatitis C virus (HCV). The rs12979860 polymorphism of the IL-28B gene participates in HCV clearance. This study investigated the association of the genetic markers (SNPs), rs5496, rs281437 and rs12979860 polymorphisms, with viral clearance and the progression of hepatic fibrosis in HCV genotype 4 patients who were treated with pegylated interferon and ribavirin. MethodsThirty consecutive HCV genotype 4 patients who were treated with pegylated interferon and ribavirin therapy for 48 weeks were grouped into responders (control group) and non-responders (case group). The severity of fibrosis was classified according to the Scheuer Score. SNP genotyping of rs5496 [A/G], rs281437 [C/T] and rs12979860 [C/T] were performed using the 5′ nuclease assay with a TaqMan MGB probe in an ABI 7500 Fast Real-Time PCR System (Applied Biosystems). ResultsAll SNPs exhibited Hardy-Weinberg Equilibrium (HWE). The patients with the C allele of rs12979860 exhibited an approximately eight times higher risk of SVR compared to patients with the T allele (aOR=7.98; CI: 1.07–59.36, P=0.012). No significant association of rs5496 and rs281437 with treatment response was detected (P=0.185 and P=0.123, respectively). Patients with the T allele of rs281437 exhibited an approximately 13 times higher risk of severe fibrosis compared to patients with the C allele (aOR=13.0; CI: 1.32–128.11, P= 0.028). No significant association of the other genetic variants with the degree of fibrosis in the study subjects was detected for rs5496 and rs12979860. ConclusionThe present study revealed associations between the ICAM-1 gene marker, rs281437, and the progression of hepatic fibrosis in HCV genotype 4 and rs12979860 of the IL-28 B gene with viral clearance.
راعي المشروعThis study was supported by a grant from the HMC and Qatar University.
اللغةen
الناشرElsevier
الموضوعgenomic DNA
hepatitis C
العنوانGenetic polymorphisms of ICAM 1 and IL28 as predictors of liver fibrosis severity and viral clearance in hepatitis C genotype 4
النوعArticle
الصفحات262-268
رقم العدد3
رقم المجلد37
ESSN2210-741X
dc.accessType Full Text


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