عرض بسيط للتسجيلة

المؤلفKhan, Iftikhar
المؤلفYousaf, Sakib
المؤلفSubramanian, Sneha
المؤلفKorale, Oshadie
المؤلفAlhnan, Mohamed Albed
المؤلفAhmed, Waqar
المؤلفTaylor, Kevin M.G.
المؤلفElhissi, Abdelbary
تاريخ الإتاحة2017-06-05T08:10:11Z
تاريخ النشر2015-12-30
اسم المنشورInternational Journal of Pharmaceutics
المعرّفhttp://dx.doi.org/10.1016/j.ijpharm.2015.10.002
الاقتباسIftikhar Khan, Sakib Yousaf, Sneha Subramanian, Oshadie Korale, Mohamed Albed Alhnan, Waqar Ahmed, Kevin M.G. Taylor, Abdelbary Elhissi, Proliposome powders prepared using a slurry method for the generation of beclometasone dipropionate liposomes, International Journal of Pharmaceutics, Volume 496, Issue 2, 30 December 2015, Pages 342-350
الرقم المعياري الدولي للكتاب03785173
معرّف المصادر الموحدhttp://www.sciencedirect.com/science/article/pii/S0378517315302696
معرّف المصادر الموحدhttp://hdl.handle.net/10576/5547
الملخصA novel “slurry method” was described for the preparation of proliposome powders using soya phosphatidylcholine (SPC) with cholesterol (1:1) and for incorporation of beclometasone dipropionate (BDP) at 2mole% of the total lipid phase. Proliposomes made with a range of lipid to sucrose carrier ratios were studied in terms of surface morphology using scanning electron microscopy (SEM) and thermal properties using differential scanning calorimetry (DSC). Following hydration of proliposomes, the resultant vesicles were compared to liposomes made using the traditional proliposome method, in terms of vesicle size and drug entrapment efficiency. SEM showed that sucrose was uniformly coated with lipid regardless of lipid to carrier ratio. Liposomes generated using the slurry proliposome method tended to have smaller median size than those generated with the conventional proliposome method, being in the range of 4.72–5.20μm and 5.89–7.72μm respectively. Following centrifugation of liposomes using deuterium oxide (D2O) as dispersion medium, vesicles entrapping BDP were separated as a floating creamy layer, whilst the free drug was sedimented as crystals. Drug entrapment was dependent on formulation composition and preparation method. When 1:15 w/w lipid to carrier was used, liposomes generated using the slurry method had an entrapment efficiency of 47.05% compared to 18.67% for those generated using the conventional proliposome method. By contrast, liposomes made by the thin-film hydration method had an entrapment efficiency of 25.66%. DSC studies using 50mole% BDP demonstrated that the drug was amorphous in the proliposome formulation and tended to crystallize on hydration, resulting in low drug entrapment. In conclusion, a novel approach to the preparation of proliposomes using a slurry method has been introduced, offering higher entrapment for BDP than liposomes made using the conventional proliposome method and those prepared by thin-film hydration technique.
اللغةen
الناشرElsevier
الموضوعCharacterization
Drug development
Proliposome
Liposome
Manufacture
العنوانProliposome powders prepared using a slurry method for the generation of beclometasone dipropionate liposomes
النوعArticle
الصفحات342-350
رقم العدد2
رقم المجلد496
dc.accessType Abstract Only


الملفات في هذه التسجيلة

الملفاتالحجمالصيغةالعرض

لا توجد ملفات لها صلة بهذه التسجيلة.

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة