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المؤلفIbrahim, Abed Alqader
المؤلفNsairat, Hamdi
المؤلفAl-Sulaibi, Mazen
المؤلفEl-Tanani, Mohamed
المؤلفJaber, Areej M.
المؤلفLafi, Zainab
المؤلفBarakat, Rahmeh
المؤلفAbuarqoub, Duaa Azmi
المؤلفMahmoud, Ismail Sami
المؤلفObare, Sherine O.
المؤلفAljabali, Alaa A.A.
المؤلفAlkilany, Alaaldin M.
المؤلفAlshaer, Walhan
تاريخ الإتاحة2024-06-23T07:07:34Z
تاريخ النشر2024-04-21
اسم المنشورExpert Opinion on Drug Delivery
المعرّفhttp://dx.doi.org/10.1080/17425247.2024.2343882
الاقتباسIbrahim, A. A., Nsairat, H., Al-Sulaibi, M., El-Tanani, M., Jaber, A. M., Lafi, Z., ... & Alshaer, W. (2024). Doxorubicin conjugates: a practical approach for its cardiotoxicity alleviation. Expert Opinion on Drug Delivery, 21(3), 399-422.
الرقم المعياري الدولي للكتاب1742-5247
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85191162839&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/56164
الملخصIntroduction: Doxorubicin (DOX) emerges as a cornerstone in the arsenal of potent chemotherapeutic agents. Yet, the clinical deployment of DOX is tarnished by its proclivity to induce severe cardiotoxic effects, culminating in heart failure and other consequential morbidities. In response, a panoply of strategies has undergone rigorous exploration over recent decades, all aimed at attenuating DOX’s cardiotoxic impact. The advent of encapsulating DOX within lipidic or polymeric nanocarriers has yielded a dual triumph, augmenting DOX’s therapeutic efficacy while mitigating its deleterious side effects. Areas covered: Recent strides have spotlighted the emergence of DOX conjugates as particularly auspicious avenues for ameliorating DOX-induced cardiotoxicity. These conjugates entail the fusion of DOX through physical or chemical bonds with diminutive natural or synthetic moieties, polymers, biomolecules, and nanoparticles. This spectrum encompasses interventions that impinge upon DOX’s cardiotoxic mechanism, modulate cellular uptake and localization, confer antioxidative properties, or refine cellular targeting. Expert opinion: The endorsement of DOX conjugates as a compelling stratagem to mitigate DOX-induced cardiotoxicity resounds from this exegesis, amplifying safety margins and the therapeutic profile of this venerated chemotherapeutic agent. Within this ambit, DOX conjugates stand as a beacon of promise in the perpetual pursuit of refining chemotherapy-induced cardiac compromise.
اللغةen
الناشرTaylor & Francis
الموضوعAnthracyclines
bioconjugation
cardiotoxicity
doxorubicin
free radicals
therapeutic index
العنوانDoxorubicin conjugates: a practical approach for its cardiotoxicity alleviation
النوعArticle
الصفحات399-422
رقم العدد3
رقم المجلد21
ESSN1744-7593
dc.accessType Abstract Only


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