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    Black Titania Janus Mesoporous Nanomotor for Enhanced Tumor Penetration and Near-Infrared Light-Triggered Photodynamic Therapy

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    lv-et-al-2024-black-titania-janus-mesoporous-nanomotor-for-enhanced-tumor-penetration-and-near-infrared-light-triggered.pdf (13.15Mb)
    Date
    2024
    Author
    Lv, Kexin
    Hou, Mengmeng
    Kou, Yufang
    Yu, Hongyue
    Liu, Mengli
    Zhao, Tiancong
    Shen, Jiacheng
    Huang, Xirui
    Zhang, Jie
    Mady, Mohamed F.
    Elzatahry, Ahmed A.
    Li, Xiaomin
    Zhao, Dongyuan
    ...show more authors ...show less authors
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    Abstract
    Thanks to their excellent photoelectric characteristics to generate cytotoxic reactive oxygen species (ROS) under the light-activation process, TiO2 nanomaterials have shown significant potential in photodynamic therapy (PDT) for solid tumors. Nevertheless, the limited penetration depth of TiO2-based photosensitizers and excitation sources (UV/visible light) for PDT remains a formidable challenge when confronted with complex tumor microenvironments (TMEs). Here, we present a H2O2-driven black TiO2 mesoporous nanomotor with near-infrared (NIR) light absorption capability and autonomous navigation ability, which effectively enhances solid tumor penetration in NIR light-triggered PDT. The nanomotor was rationally designed and fabricated based on the Janus mesoporous nanostructure, which consists of a NIR light-responsive black TiO2 nanosphere and an enzyme-modified periodic mesoporous organosilica (PMO) nanorod that wraps around the TiO2 nanosphere. The overexpressed H2O2 can drive the nanomotor in the TME under catalysis of catalase in the PMO domain. By precisely controlling the ratio of TiO2 and PMO compartments in the Janus nanostructure, TiO2&PMO nanomotors can achieve optimal self-propulsive directionality and velocity, enhancing cellular uptake and facilitating deep tumor penetration. Additionally, by the decomposition of endogenous H2O2 within solid tumors, these nanomotors can continuously supply oxygen to enable highly efficient ROS production under the NIR photocatalysis of black TiO2, leading to intensified PDT effects and effective tumor inhibition.
    DOI/handle
    http://dx.doi.org/10.1021/acsnano.4c03652
    http://hdl.handle.net/10576/60806
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    • Chemistry & Earth Sciences [‎601‎ items ]
    • Mathematics, Statistics & Physics [‎786‎ items ]

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