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A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway
( Mary Ann Liebert , 2017 , Article)This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use ... -
Comparative Outer Membrane Protein Analysis of High and Low-Invasive Strains of Cronobacter malonaticus
( Frontiers Media , 2017 , Article)are an important group of foodborne pathogens that has been linked to life-threatening infections in both infants and adults. The major infections associated with species are neonatal meningitis, necrotizing enterocolitis, ... -
Genetically unmatched human iPSC and ESC exhibit equivalent gene expression and neuronal differentiation potential.
( Nature Publishing Group , 2017 , Article)The potential uniformity between differentiation and therapeutic potential of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) remains debatable. We studied the gene expression profiles, ... -
Prevalence and molecular profiling of Epstein Barr virus (EBV) among healthy blood donors from different nationalities in Qatar.
( Public Library of Science , 2017 , Article)The Epstein-Barr virus (EBV) is the causative agent of infectious mononucleosis. EBV is highly prevalent lymphotropic herpesvirus and has been linked to several malignancies. Transmission is generally by oral secretions, ... -
Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling
( Elsevier , 2017 , Article)Aortic valve diseases are among the most common cardiovascular defects. Since a non-functioning valve results in disturbed blood flow conditions, the diagnosis of such defects is based on identification of stenosis via ... -
Generating an imagingbased approach for enhanced structural and functional analysis of zebrafish cardiovascular systems
( HBKU Press , 2018 , Conference Proceedings)Cardiovascular diseases (CVDs) have latterly become one of the leading cause of death and impairment worldwide. According to the World Health Organization (WHO), data estimation in 2008 were about 17.3, 7.3 and 6.2 million ... -
Novel CD44-downstream signaling pathways mediating breast tumor invasion
( Ivyspring International Publisher , 2018 , Article Review)CD44, also known as homing cell adhesion molecule is a multi-structural cell molecule involved in cell-cell and cell-extracellular matrix communications. CD44 regulates a number of central signaling pathways, including ... -
Editorial: Arterial aging and age-associated arterial diseases
( Frontiers Media S.A. , 2018 , Other)[No abstract available] -
Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction
( Portland Press Ltd , 2018 , Article)The most common inherited cardiac disorder, hypertrophic cardiomyopathy (HCM), is characterized by thickening of heart muscle, for which genetic mutations in cardiac myosin-binding protein C3 (c-MYBPC3) gene, is the leading ... -
Geographical distribution of air pollution in Doha Qatar
( Hamad bin Khalifa University Press (HBKU Press) , 2018 , Conference Paper)Urban air pollution is an inevitable consequence of the urbanization representing a growing concern to scientists, policymakers and an increasing fraction of the population. Air pollution is an acute problem especially in ... -
The Cellular Interplay Between CD44 and Na+/H+ Exchanger1 in Cardiac Remodeling
( Hamad bin Khalifa University Press (HBKU Press) , 2018 , Conference Paper)Background: Extracellular matrix (ECM) remodeling is a characteristic feature of cardiac remodeling which, if left untreated, progresses to heart failure. Cardiac fibroblasts, the major cellular component of the myocardium, ... -
Viscoelastic behaviour of Bovine Myocardiam and valvular tissue: Applications in Bio prosthetic heart valve with enhanced properties
( Hamad bin Khalifa University Press (HBKU Press) , 2018 , Conference Paper)Cardiovascular diseases are among the major causes of morbity and mortality. Particularly, the prevalence of heart valve disease(damaged heart valve leaflet) is one of the most common ailment. In elderly people, every year ... -
Nox2 activity is required in obesity-mediated alteration of bone remodeling
( Hindawi Limited , 2018 , Article)Despite increasing evidence suggesting a role for NADPH oxidases (Nox) in bone pathophysiology, whether Nox enzymes contribute to obesity-mediated bone remodeling remains to be clearly elucidated. Nox2 is one of the ... -
Antibiotic Resistance Profile of Commensal Escherichia coli Isolated from Broiler Chickens in Qatar.
( International Association for Food Protection , 2018 , Article)Antibiotic resistance (AR) is a growing public health concern worldwide, and it is a top health challenge in the 21st century. AR among Enterobacteriaceae is rapidly increasing, especially in third-generation cephalosporins ... -
Elaeagnus angustifolia Plant Extract Inhibits Angiogenesis and Downgrades Cell Invasion of Human Oral Cancer Cells via Erk1/Erk2 Inactivation.
( Taylor & Francis (Routledge) , 2018 , Article)Oral cancer is a common malignancy in both men and women worldwide; this cancer is characterized by a marked propensity for invasion and spreading to local lymph nodes. On the other hand, Elaeagnus angustifolia (EA) is a ... -
Denaturing Gradient Gel Electrophoresis-Polymerase Chain Reaction Comparison of Chitosan Effects on Anaerobic Cultures of Broiler Cecal Bacteria and Salmonella Typhimurium.
( Mary Ann Liebert , 2018 , Article)Enteropathogen colonization and product contamination are major poultry industry problems. The emergence of antibiotic resistance, and associated risks to human health, is limiting the use of antibiotics as first-line ... -
Zebrafish larvae as a model to demonstrate secondary iron overload.
( Wiley , 2018 , Article)Thalassemia is the most common genetically inherited blood disorder arising from a defect in hemoglobin production, resulting in ineffective erythropoiesis and severe hemolytic anemia. While transfusion therapy corrects ... -
Herpes Simplex Virus Type 2 Seroprevalence Among Different National Populations of Middle East and North African Men
( Lippincott, Williams & Wilkins , 2018 , Article)BACKGROUND: There are limited data on herpes simplex virus type 2 (HSV-2) seroprevalence in the Middle East and North Africa (MENA). We examined country- and age-specific HSV-2 seroprevalence among select MENA populations ... -
HER-2/Epstein-Barr virus crosstalk in human gastric carcinogenesis: A novel concept of oncogene/oncovirus interaction.
( Taylor & Francis , 2018 , Article)Gastric cancer is the fourth most common cancer and the second leading cause of cancer deaths worldwide. Additionally, it is well-known that metastatic cancer disease is a major cause of morbidity and mortality in cancer ... -
In vivo Analysis of Clausena anisata (Willd.) Hook. f. ex Benth Crude and SNP Extracts Against Antioxidant and Hypoglycemic Activity
( DYR Labs Pvt. Ltd. , 2018 , Article)Type II diabetes mellitus which is a chronic metabolic disorder is characterized by insulin resistance. Due to the serious side effects of synthetic antidiabetic drugs, the search for safer and more efficacious hypoglycemic ...