Biomedical Research Center
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Biomedical Research Center Research [755 items ]
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Eight weeks of aerobic exercise, but not four, improves insulin sensitivity and cardiovascular performance in young women
( Nature Research , 2025 , Article)Regular aerobic exercise has a significant impact on glucose metabolism and lipid profiles, contributing to overall health improvement. However, evidence for optimal exercise duration to achieve these effects is limited. ... -
Unveiling GATA3 Signaling Pathways in Health and Disease: Mechanisms, Implications, and Therapeutic Potential
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article Review)GATA binding protein 3 (GATA3), a member of the GATA family transcription factors, is a key player in various physiological and pathological conditions. It is known for its ability to bind to the DNA sequence "GATA", which ... -
Metformin-loaded nanoparticles reduce hyperglycemia-associated oxidative stress and induce eNOS phosphorylation in vascular endothelial cells
( Nature Research , 2024 , Article)Diabetes mellitus is a chronic disease characterized by metabolic defects, including insulin deficiency and resistance. Individuals with diabetes are at increased risk of developing cardiovascular complications, such as ... -
Oncoproteins E6/E7 of the human papillomavirus types 16 & 18 synergize in modulating oncogenes and tumor suppressor proteins in colorectal cancer
( Taylor and Francis Ltd. , 2025 , Article)Objective Our study presents a novel analysis of the oncogenes and tumor suppressor proteins directly modulated by E6/E7 of high-risk HPV types 16 and 18, in colorectal cancer (CRC). Methods HCT 116 (KRAS mutant) & ... -
Metabarcoding analysis of oral microbiome during pregnancy
( Frontiers Media SA , 2024 , Article)Pregnancy is a dynamic physiological process involving significant hormonal, immune, and metabolic changes to support fetal growth and development. This study investigates the changes in salivary microbiome and biochemical ... -
GATA3: Orchestrating cellular fate through differentiation and proliferation
( Elsevier , 2025 , Article Review)Cell proliferation and differentiation are two fundamental biological processes that occur in biological systems, tightly regulated by various factors such as transcription factors (TFs). Zinc finger proteins are TFs ... -
Mindray CL-900i assay: An effective assay for hepatitis B surface antigen screening with superior specificity
( Elsevier , 2025 , Article)Objectives The chemiluminescence immunoassay automated Abbott ARCHITECT hepatitis B surface antigen (HBsAg) screening assay is globally recognized for its superior sensitivity but notably low specificity. This mandates ... -
Molecular identification and characterization of waterborne protozoa among stranded Dugong dugon
( Elsevier , 2025 , Article)The Persian Gulf hosts the second-largest population of Dugongs. The International Union for the Conservation of Nature (IUCN) lists them as Vulnerable to Extinction species. Incidental fishing, vessel strikes, environmental ... -
Current status and innovative developments of CAR-T-cell therapy for the treatment of breast cancer
( BioMed Central Ltd , 2025 , Article Review)Breast cancer will overtake all other cancers in terms of diagnoses in 2024. Breast cancer counts highest among women in terms of cancer incidence and death rates. Innovative treatment approaches are desperately needed ... -
3D printing flexible Ga-doped ZnO films for wearable energy harvesting: thermoelectric and piezoelectric nanogenerators
( Springer , 2024 , Article)The 3D printing of energy harvesters using earth-abundant and non-toxic elements promotes energy sustainability and market competitiveness. The semiconducting behavior and non-centrosymmetric wurtzite crystal structure of ... -
Scalable fabrication of flexible thermoelectric generator with non-toxic Ga:ZnO and PEDOT:PSS thermoelements for wearable energy harvesting
( Elsevier , 2025 , Article)This study presents a lightweight, flexible thermoelectric generator (TEG) designed for sustainable energy harvesting in wearable electronics. The TEG integrates p-type PEDOT:PSS and n-type Ga:ZnO thermoelements, utilizing ... -
A Decade of Discovery of Huntington's Disease Biomarkers: A Comprehensive Review of its Established and Emerging Bi-omarkers
( preprints , 2024 , Article Review)Neurodegenerative disorders (NDs) lead to progressive neuronal loss in various brain regions and are a significant public health concern, with NDs expected to become the second-leading cause of death globally within the ... -
Ethnobotanical survey of medicinal plants used in management of breast cancers in Qatar
( Elsevier , 2025 , Article)Breast cancer is a global health concern, including in Qatar, where it impacts women significantly. The complexity of breast cancer requires diverse treatment approaches influenced by tumor characteristics and biology. ... -
Advances in Huntington’s Disease Biomarkers: A 10-Year Bibliometric Analysis and a Comprehensive Review
( MDPI , 2025 , Article Review)Neurodegenerative disorders (NDs) cause progressive neuronal loss and are a significant public health concern, with NDs projected to become the second leading global cause of death within two decades. Huntington’s disease ... -
Trends in Bacterial and Candida Infections Before and Throughout the COVID-19 Pandemic
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)virus, resulted in significant global health consequences. The interventions introduced to limit the spread of the virus had a ... -
Comparative Analysis of In Vitro Pumps Used in Cardiovascular Investigations: Focus on Flow Generation Principles and Characteristics of Generated Flows
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)A comprehensive analysis of in vitro pumps used in cardiovascular research is provided in this review, with a focus on the characteristics of generated flows and principles of flow generations. The cardiovascular system, ... -
Generation of Novel Tumour-Selective SEA Superantigen-Based Peptides with Improved Safety and Efficacy for Precision Cancer Immunotherapy
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Bacterial superantigens are T-cell-stimulatory protein molecules which produce massive cytokines and cause human diseases. Due to their ability to activate up to 20% of resting T-cells, they have effectively killed ... -
Identification of KSR2 Variants in Pediatric Patients with Severe Early-Onset Obesity from Qatar
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)The kinase suppressor of Ras 2 (KSR2) gene is associated with monogenic obesity, and loss-of-function variants in KSR2 have been identified in individuals with severe early-onset obesity. This study investigated KSR2 ... -
Alterations in Choline Metabolism in Non-Obese Individuals with Insulin Resistance and Type 2 Diabetes Mellitus
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)The prevalence of non-obese individuals with insulin resistance (IR) and type 2 diabetes (T2D) is increasing worldwide. This study investigates the metabolic signature of phospholipid-associated metabolites in non-obese ... -
BNT162b2 Versus mRNA-1273 Vaccines: Comparative Analysis of Long-Term Protection Against SARS-CoV-2 Infection and Severe COVID-19 in Qatar
( Wiley , 2024 , Article)Background: This study provides a head-to-head comparison of the protection provided by the BNT162b2 and mRNA-1273 vaccines against SARS-CoV-2 infection and against severe COVID-19, covering primary series and third ...
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