Biomedical Research Center
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Biomedical Research Center Research [783 items ]
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Adipose-Derived Stromal Cells and Cancer-Associated Fibroblasts: Interactions and Implications in Tumor Progression
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Adipose-derived stromal cells (ASCs) and cancer-associated fibroblasts (CAFs) play pivotal roles in the tumor microenvironment (TME), significantly influencing cancer progression and metastasis. This review explores the ... -
Abstract 16: Differential stemness properties in bone marrow-derived mesenchymal stem cells from healthy subjects and from patients with acute myeloid leukemia
( American Association for Cancer Research , 2025 , Conference)Study purpose: The imidazoquinoxaline EAPB0503, an imiquimod analogue, exhibits immunomodulatory and anti-cancer properties against several blood malignancies, including acute myeloid leukemia (AML). The bone marrow (BM) ... -
Prevalence of syphilis infection among migrant workers in Qatar: a nationwide cross-sectional survey
( BMJ Publishing Group , 2024 , Article)Objectives Scant data are available on syphilis infection within migrant populations worldwide and in the population of the Middle East and North Africa region. This study investigated the prevalence of both lifetime and ... -
Beyond the Injury: How Does Smoking Impair Stem Cell-Mediated Repair Mechanisms? A Dual Review of Smoking-Induced Stem Cell Damage and Stem Cell-Based Therapeutic Applications.
( Springer Nature , 2025 , Article)While the literature on molecular and clinical effects of smoking on the lungs and other organs has been expansively reviewed, there is no comprehensive compilation of the effects of smoking on stem cell (SC) populations. Recent ... -
gnas Knockdown Induces Obesity and AHO Features in Early Zebrafish Larvae
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)GNAS (Guanine Nucleotide-Binding Protein, Alpha Stimulating) is a complex gene that encodes the alpha subunit of the stimulatory G protein (Gsα), critical for signaling through various G protein-coupled receptors. Inactivating ... -
Advancements in precision medicine: multi-omics approach for tailored metformin treatment in type 2 diabetes
( Frontiers Media SA , 2024 , Article Review)Metformin has become the frontline treatment in addressing the significant global health challenge of type 2 diabetes due to its proven effectiveness in lowering blood glucose levels. However, the reality is that many ... -
Metabolic signatures of combined exercise and fasting: an expanded perspective on previous telomere length findings
( Frontiers Media SA , 2024 , Article)Introduction: Aging is a complex process marked by a gradual decline in physiological function and increased susceptibility to diseases. Telomere length is frequently regarded as one of the primary biomarkers of aging. ... -
Efficacy and safety of daratumumab for the treatment of refractory/relapsed multiple myeloma. A systematic review of meta-analyses
( SAGE Publications Ltd , 2025 , Article Review)Introduction: Several meta-analyses (MAs) of the efficacy and safety of daratumumab in refractory/relapsed multiple myeloma (RRMM) exist. They include different types of populations, Daratumumab regimens, and outcomes. ... -
Unraveling the proteomic signatures of coronary artery disease and hypercholesterolemia.
( The Association of Basic Medical Sciences , 2024 , Article)Atherosclerosis, a leading cause of coronary artery disease (CAD), is heavily influenced by hypercholesterolemia (HC). Proteomics research has shown promise in identifying biological markers for CAD diagnosis and prognosis. ... -
Evaluating the Effects of BSA-Coated Gold Nanorods on Cell Migration Potential and Inflammatory Mediators in Human Dermal Fibroblasts
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Albumin-coated gold nanoparticles display potential biomedical applications, including cancer research, infection treatment, and wound healing; however, elucidating their interaction with normal cells remains an area with ... -
Enhancing Influenza Detection through Integrative Machine Learning and Nasopharyngeal Metabolomic Profiling: A Comprehensive Study
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Background/Objectives: Nasal and nasopharyngeal swabs are commonly used for detecting respiratory viruses, including influenza, which significantly alters host cell metabolites. This study aimed to develop a machine learning ... -
Seroprevalence and detection of Human herpesvirus-8 (HHV-8) among healthy blood donors residing in Qatar
( Elsevier , 2024 , Article)BackgroundHuman herpesvirus 8 (HHV-8) is a critical causative agent behind Kaposi sarcoma (KS), an oncogenic disease with profound consequences in immunocompromised individuals. Studies suggested HHV-8 seroprevalence in ... -
Combining Gram stain and 16S qPCR improved diagnostic accuracy for suspected pneumonia and could become a new metric in the rapid diagnosis of lower respiratory tract infections
( Microbiology Society , 2024 , Article)Introduction. The frequency of multidrug-resistant organisms (MDROs) in hospitals and the risk of delaying effective treatment result in the culture of respiratory secretions for nearly all patients with suspected pneumonia. ... -
Beyond nutrition: The emerging therapeutic potential landscape of breast milk-derived extracellular vesicles
( Elsevier , 2025 , Article)Breastfeeding is widely recognized for its essential nutritional benefits and broader biological impacts. Beyond providing infants with a balanced mix of vitamins, proteins, and fats critical for growth and development, ... -
Understanding Heritable Variation Among Hosts in Infectious Diseases Through the Lens of Twin Studies
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article Review)Genetic factors have been hypothesized to contribute to the heterogeneity in the response to infectious diseases (IDs). The classical twin design provides a powerful tool to estimate the role of genetic contributions to ... -
The influence of circadian rhythm disruption during Ramadan on metabolic responses to physical activity: a pilot study
( Frontiers Media SA , 2025 , Article)Background: Circadian rhythms and sleep patterns are important regulators of metabolic health. During Ramadan intermittent fasting (RIF), the sleep–wake cycles are often disrupted, which can affect physical activity (PA) ... -
Chromosome-level reference genome assembly of the gyrfalcon (Falco rusticolus) and population genomics offer insights into the falcon population in Mongolia
( Nature Research , 2025 , Article)The taxonomic classification of a falcon population found in the Mongolian Altai region in Asia has been heavily debated for two centuries and previous studies have been inconclusive, hindering a more informed conservation ... -
First report of serological, molecular detection, and characterization of human parvovirus B19 infections among sickle cell anaemia patients in Khartoum State, Sudan
( Elsevier , 2025 , Article)BackgroundPatients with haematological disorders, such as sickle cell anaemia, are at an elevated risk of transient aplastic crisis due to parvovirus B19 infection. The virus targets specific integration sites in the human ... -
S.I.: Emerging material science trends in Nanomedicine, Biosensor, Microfluidics and 3D Bioprinting technologies
( Springer , 2025 , Article)Emergent Materials has focused on applying new materials science and technologies, particularly in fast-growing areas. One such field is the biological applications of materials, i.e. Biomaterials. With this objective in ... -
Finite Element Analysis of Evolut Transcatheter Heart Valves: Effects of Aortic Geometries and Valve Sizes on Post-TAVI Wall Stresses and Deformations
( MDPI , 2025 , Article)Background/Objectives: For transcatheter aortic valve implantation (TAVI) therapy, a catheter-guided crimped valve is deployed into the aortic root. Valve types such as Edwards balloon-expandable valves and Medtronic ...
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