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Impact of single-walled carbon nanotubes on the embryo: a brief review

Al Moustafa, Ala-Eddin; Mfoumou, Etienne; Roman, Dacian E.; Nerguizian, Vahe; Alazzam, Anas; ... more authors ... less authors ( Dove Press , 2016 , Article)

Carbon nanotubes (CNTs) are considered one of the most interesting materials in the 21st century due to their unique physiochemical characteristics and applicability to various industrial products and medical applications. ...

E5 and E6/E7 of high-risk HPVs cooperate to enhance cancer progression through EMT initiation

Al Moustafa, Ala-Eddin ( Taylor & Francis , 2015 , Article)

It is estimated that 10–20% of human carcinogenesis is linked to virus infection including papillomaviruses (HPVs). Moreover, since metastatic cancer disease is a major cause of morbidity and mortality in cancer patients, ...

Preparation, characterization, and in ovo vaccination of dextran-spermine nanoparticle DNA vaccine coexpressing the fusion and hemagglutinin genes against Newcastle disease

Firouzamandi, Masoumeh; Moeini, Hassan; Hosseini, Seyed Davood; Bejo, Mohd Hair; Omar, Abdul Rahman; ... more authors ... less authors ( Dove Press , 2016 , Article)

Plasmid DNA (pDNA)-based vaccines have emerged as effective subunit vaccines against viral and bacterial pathogens. In this study, a DNA vaccine, namely plasmid internal ribosome entry site-HN/F, was applied in ovo against ...

Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation

Villar, Rina F.; Patel, Jinal; Weaver, Grant C.; Kanekiyo, Masaru; Wheatley, Adam K.; ... more authors ... less authors ( Nature Publishing Group , 2016 , Article)

Activation of immune cells (but not B cells) with lectins is widely known. We used the structurally defined interaction between influenza hemagglutinin (HA) and its cell surface receptor sialic acid (SA) to identify a B ...

Cytotoxicity and physicochemical characterization of iron–manganese-doped sulfated zirconia nanoparticles

Al-Fahdawi, Mohamed Qasim; Rasedee, Abdullah; Al-Qubaisi, Mothanna Sadiq; Alhassan, Fatah H.; Rosli, Rozita; ... more authors ... less authors ( Dove Press , 2015 , Article)

Iron–manganese-doped sulfated zirconia nanoparticles with both Lewis and Brønsted acidic sites were prepared by a hydrothermal impregnation method followed by calcination at 650°C for 5 hours, and their cytotoxicity ...

Common and Rare Genetic Variants Associated With Alzheimer's Disease

Marei, Hany E.; Althani, Asmaa; Suhonen, Jaana; El Zowalaty, Mohamed E.; Albanna, Mohammad A.; ... more authors ... less authors ( WILEY PERIODICALS, INC. , 2016 , Article)

Alzheimer's disease (AD) is one of the most devastating disorders. Despite the continuing increase of its incidence among aging populations, no effective cure has been developed mainly due to difficulties in early diagnosis ...

Landscape of NAT2 polymorphisms among breast cancer.

Tengfei, Wang; Marei, Hany E. ( Elsevier Masson , 2016 , Article)

PURPOSE: The prevalence of phenotypes of Arylamine N-acetyltransferase-2(NAT2) gene (i.e. fast, intermediate and slow acetylators) among ethnic groups, as well as the association studies regarding NAT2 polymorphisms and ...

PDGFRα depletion attenuates glioblastoma stem cells features by modulation of STAT3, RB1 and multiple oncogenic signals.

Cenciarelli, Carlo; Marei, Hany E.; Felsani, Armando; Casalbore, Patrizia; Sica, Gigliola; ... more authors ... less authors ( Impact Journals , 2016 , Article)

Platelet derived growth factor receptors (PDGFRs) play an important role in tumor pathogenesis, and they are frequently overexpressed in glioblastoma (GBM). Earlier we have shown a higher protein expression of PDGFR isoforms ...

Recent Perspective About the Amyloid Cascade Hypothesis and Stem Cell-Based Therapy in the Treatment of Alzheimer's Disease

Marei, Hany E.; Althani, Asmaa; Suhonen, Jaana; El Zowalaty, Mohamed E.; Albanna, Mohammad A.; ... more authors ... less authors ( Bentham Science , 2016 , Book chapter)

Alzheimer's disease (AD) is a complex neurodegenerative condition that is clinically characterized by impaired cognitive functions. The major morphologically observed lesion of AD encompasses the accumulation of extracellular ...

Pre-fusion structure of a human coronavirus spike protein

Kirchdoerfer, Robert N.; Cottrell, Christopher A.; Wang, Nianshuang; Pallesen, Jesper; Yassine, Hadi M.; ... more authors ... less authors ( Nature Publishing Group , 2015 , Article)

HKU1 is a human betacoronavirus that causes mild yet prevalent respiratory disease1, and is related to the zoonotic SARS2 and MERS3 betacoronaviruses, which have high fatality rates and pandemic potential. Cell tropism ...