Notch Signaling in Health and Disease

Abstract

The Notch signaling pathway, a vital and evolutionarily conserved regulator of cellular processes, intricately shapes both health and disease. In the realm of health, Notch signaling assumes a pivotal role in the skin homeostasis, orchestrating primary growth arrest and progressive keratinocyte differentiation processes [1]. Moreover, Notch signaling is also critical in other adult organs and tissues such as the liver, intestine, hematopoietic system, and skeletal muscle. Its involvement in immune cell homeostasis and organ-specific immune responses accentuates its overarching significance in overall immune function [2]. Moreover, the pathway contributes to the integrity of the vasculature, the development of smooth muscle cells, and intricate processes such as osteogenic differentiation, highlighting its versatile role in maintaining physiological balance. Conversely, dysregulation of Notch signaling is implicated in an array of diseases. In cancer, aberrant Notch activation is intricately linked to tumor initiation, progression, and chemoresistance across various malignancies [3]. Cardiovascular disorders, exemplified by myocardial infarction, showcase the cardioprotective effects of Notch signaling [4], while neurological conditions like Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) underscore its role in hereditary strokes [5]. In essence, unraveling the nuanced dynamics of Notch signaling is paramount for understanding the molecular underpinnings of diseases and harnessing its therapeutic potential. The multifaceted involvement of Notch signaling in health and disease underscores its intricate nature, positioning it as a promising avenue for targeted interventions and personalized medicine.