Browsing Laboratory Animal Research Center by Author "Varadharajan, Kavitha"

Now showing items 1-7 of 7

    • Cadmium: An Emerging Role in Adipose Tissue Dysfunction 

      Attia, Sarra Mohammed; Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Das, Sandra Concepcion; Al-Naemi, Hamda A. ( Springer , 2021 , Article Review)
      Cadmium (Cd) is a toxic heavy metal that is widespread in the environment due to the substantial anthropogenic inputs from the agriculture and industrial sectors. The toxic impact of Cd adversely affects human health and ...

    • Chronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley Rat 

      Das, Sandra Concepcion; Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Al-Naemi, Hamda A. ( Frontiers Media , 2021 , Article)
      The aim of this study was to evaluate the role of chronic cadmium exposure in modulating cardiac matrix metalloproteinases (MMPs) in the heart of rats. Adult male Sprague-Dawley rats were exposed to 15 ppm CdCl2 in drinking ...

    • Early-Life Sugar Consumption Affects the Microbiome in Juvenile Mice 

      Alasmar, Reem Moath; Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Al-Naemi, Hamda A. ( John Wiley and Sons Inc , 2022 , Article)
      Scope: The composition of the gut microbiota is influenced by the dietary nutrient. Sugar has been linked with many metabolic health disorders such as heart disease, metabolic syndrome, and immune disorders. Long-term ...

    • Effect of CARMA 2sh gene in Mouse embryonic stem (ES) cells 

      Shanmugakonar, Muralitharan; Varadharajan, Kavitha; Vito, Pasquale (2017 , Poster)
      CARMA2 belongs to the CARMA family of proteins. They are involved in the regulation and activation of NF-κB that have a central role in the control of immune and inflammatory response, and cell survival and proliferation. ...

    • Expression of active and inactive forms of CIK and CARMA 2sh proteins in Normal Human Epidermal Keratinocytes (NHEK) 

      Shanmugakonar, Muralitharan; Varadharajan, Kavitha; Vito, Pasquale (2016 , Poster)
      Psoriasis is a debilitating skin disease affecting approximately 23% of human population. The disease is considered to have key genetic underpinning and genome wide association studies and meta analysis have identified ...

    • Gut Microbiota Dysbiosis and Their Impact on Biochemical and Inflammatory Profiles in Cafeteria Diet Fed Sprague Dawley Rats 

      Alasmar, Reem Moath; Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Al-Naemi, Hamda A. ( Scientific Research Publishing , 2019 , Article)
      Gut microbiota plays a major role in regulating the host metabolism and immune system. However, the structure of microbiome population is altered constantly by diverse factors including diet and environment. In particular, ...

    • Gut Microbiota Dysbiosis in Cafeteria Diet Fed Sprague Dawley Rats 

      Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Das, Sandra Concepcion; Al-Naemi, Hamda A. ( Scientific Research Publishing , 2018 , Article)
      Diet plays a major role in the body physiology and metabolism. The quantity, nature and stability of the macronutrients present in the diet have a major impact on the composition of gut microbiota. Gut microbiota plays a ...