Laboratory Animal Research Center
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Laboratory Animal Research Center (Research) [136 items ]
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Molecular Screening and Free Energy Calculations-Based Exploration of Medicinal Phytocompounds Chemical Space to Abrogate G9R-E4R Complex from Monkeypox: A Current Global Health Threat
( Wiley-VCH , 2025 , Article)The current monkeypox virus outbreak is probably linked with the novel substitutions in the G9R protein of the replication complex. The G9R-E4R interface act as a potential druggable site for the inhibition of monkeypox ... -
JAK-STAT Signaling in Autoimmunity and Cancer
( Dove Medical Press Ltd , 2025 , Article Review)The JAK-STAT pathway is an essential cell survival signaling that regulates gene expressions related to inflammation, immunity and cancer. Cytokine receptors, signal transducer and activator of transcription (STAT) proteins, ... -
Curcumin induces apoptosis via downregulation of SKP2 and induction of GADD45A/CDKN1A expression through generation of ROS in cutaneous T-cell lymphoma cells
( Elsevier , 2025 , Article)Curcumin, a plant derived natural product isolated from Curcuma longa. The aim of this study is to investigate the anti-proliferative effects and the underlying mechanisms of curcumin in Cutaneous T cell lymphoma (CTCL), ... -
Phytocompounds as potential inhibitors of p300-HIF1α interaction: A structure-based screening and molecular dynamics simulation analysis
( Society for Medicinal Plant and Natural Product Research (GA) - the Italian Society of Phytochemistry (SIF) , 2025 , Poster)Hypoxia plays a key role in cancer progression, mainly by stabilizing and activating hypoxia-inducible factor-1 (HIF-1) [1]. For HIF-1 to function under low oxygen conditions, it must interact with the transcriptional ... -
In vitro and in silico analysis of anticancer activity of terpenoids of Dittrichia viscosa (L.) Greuter essential oil
( Society for Medicinal Plant and Natural Product Research (GA) - the Italian Society of Phytochemistry (SIF) , 2025 , Poster)There is a continuous global search for new anticancer agents from natural sources. In this study, the essential oils of Dittrichia viscosa (L.) Greuter leaves (DVEO) were extracted by hydrodistillation and chemically ... -
Antiproliferative activity of sesquiterpene lactones from Dittrichia viscosa (L.) Greuter: In vitro and in silico studies
( Society for Medicinal Plant and Natural Product Research (GA) - the Italian Society of Phytochemistry (SIF) , 2025 , Poster)Plant-derived metabolites have provided promising leads in the search for safer anticancer chemo-therapies. Among these, sesquiterpene lactones, predominantly present in the genus of the Aster-aceae family, exhibit great ... -
Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1? Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background: Hypoxia plays a key role in cancer progression, mainly by stabilizing and activating hypoxia-inducible factor-1 (HIF-1). For HIF-1 to function under low oxygen conditions, it must interact with the transcriptional ... -
Association between maternal exposure to polycyclic aromatic hydrocarbons and birth anthropometric outcomes: A systematic review and meta-analysis
( Elsevier , 2024 , Article Review)BackgroundPrevious research has proposed that exposure to polycyclic aromatic hydrocarbons (PAHs) during pregnancy could potentially lead to a higher risk of adverse birth anthropometric outcomes. However, the current ... -
The apoptotic and anti-proliferative effects of Neosetophomone B in T-cell acute lymphoblastic leukaemia via PI3K/AKT/mTOR pathway inhibition
( John Wiley and Sons Inc , 2025 , Article)The phosphatidylinositol 3-kinase/Protein Kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signalling pathway is pivotal in various cancers, including T-cell acute lymphoblastic leukaemia (T-ALL), a particularly ... -
Signaling networks guiding erythropoiesis
( Lippincott Williams and Wilkins , 2024 , Article Review)Purpose of reviewCytokine-mediated signaling pathways, including JAK/STAT, PI3K/AKT, and Ras/MAPK pathways, play an important role in the process of erythropoiesis. These pathways are involved in the survival, proliferation, ... -
Deregulated transcription factors in the emerging cancer hallmarks
( Elsevier , 2024 , Article)Cancer progression is a multifaceted process that entails several stages and demands the persistent expression or activation of transcription factors (TFs) to facilitate growth and survival. TFs are a cluster of proteins ... -
Exploiting transcription factors to target EMT and cancer stem cells for tumor modulation and therapy
( Elsevier , 2024 , Article)Transcription factors (TFs) are essential in controlling gene regulatory networks that determine cellular fate during embryogenesis and tumor development. TFs are the major players in promoting cancer stemness by regulating ... -
The cross-talk between miRNAs and JAK/STAT pathway in cutaneous T cell lymphoma: Emphasis on therapeutic opportunities
( Elsevier , 2024 , Article Review)Mycosis Fungoides (MF) and Sézary Syndrome (SS) belong to a wide spectrum of T cell lymphoproliferative disorders collectively termed cutaneous T cell lymphomas (CTCL). CTCLs represent an archetype of heterogeneous and ... -
Epigenetic control of inflammation in Atopic Dermatitis
( Elsevier , 2024 , Article Review)Atopic dermatitis (AD), also known as atopic eczema, is a common but also complex chronic, itchy skin condition with underlying inflammation of the skin. This skin ailment is prevalent worldwide and affects people of all ... -
Editorial: Experimental and computational methods in the development of diagnostics and therapeutics for colon cancer
( Frontiers Media SA , 2025 , Article)Cancer continues to be one of the major causes of illness and death worldwide. It is growing an alarming rate, and affects every geographic region of the world. Therefore, the goal is to investigate novel biomarkers both ... -
Exploring global natural product databases for NLRP3 inhibition: Unveiling novel combinatorial therapeutic strategy for hidradenitis suppurativa
( Elsevier , 2025 , Article)BackgroundHidradenitis suppurativa (HS) is a chronic inflammatory skin condition of the terminal hair follicle, which can present in sporadic, familial, or syndromic forms. The exact pathogenesis of HS remains elusive, ... -
Sigma-1 receptor engages an anti-inflammatory and antioxidant feedback loop mediated by peroxiredoxin in experimental colitis
( MDPI , 2020 , Article)Inflammatory bowel disease (IBD), comprising Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic inflammatory condition of the gastrointestinal tract. Since the treatment of IBD is still an unresolved issue, we ... -
Non-invasive biomarkers for monitoring the immunotherapeutic response to cancer
( BioMed Central Ltd , 2020 , Article Review)Immunotherapy is an efficient way to cure cancer by modulating the patient's immune response. However, the immunotherapy response is heterogeneous and varies between individual patients and cancer subtypes, reinforcing the ... -
Metformin-loaded nanoparticles reduce hyperglycemia-associated oxidative stress and induce eNOS phosphorylation in vascular endothelial cells
( Nature Research , 2024 , Article)Diabetes mellitus is a chronic disease characterized by metabolic defects, including insulin deficiency and resistance. Individuals with diabetes are at increased risk of developing cardiovascular complications, such as ... -
Unraveling molecular interconnections and identifying potential therapeutic targets of significance in obesity-cancer link
( Elsevier , 2025 , Article Review)Obesity, a global health concern, is associated with severe health issues like type 2 diabetes, heart disease, and respiratory complications. It also increases the risk of various cancers, including melanoma, endometrial, ...
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