Browsing by Subject "Anticancer"
Now showing items 1-14 of 14
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Design, Synthesis and Biological Evaluation of Novel Chalcone Analogs as Potential Therapeutic Agents for Castration-Resistant Prostate Cancer
( Qatar University Press , 2020 , Poster)Prostate cancer (PCa) is the second most frequently diagnosed malignancy, as well as a leading cause of cancer-related mortality in men globally. Despite the initial response to hormone targeted therapy, the majority of ... -
Evolving strategies and application of proteins and peptide therapeutics in cancer treatment
( Elsevier , 2023 , Article Review)Several proteins and peptides have therapeutic potential and can be used for cancer therapy. By binding to cell surface receptors and other indicators uniquely linked with or overexpressed on tumors compared to healthy ... -
Exploring the interaction of cobalt oxide nanoparticles with Albumin, leukemia cancer cells and pathogenic bacterial by multispectroscopic, docking, cellular and antibacterial approaches
( Dove Medical Press Ltd. , 2020 , Article)Aim: The interaction of NPs with biological systems may reveal useful details about their pharmacodynamic, anticancer and antibacterial effects. Methods: Herein, the interaction of as-synthesized Co3O4 NPs with HSA was ... -
Fabrication of inorganic alumina particles at nanoscale by a pulsed laser ablation technique in liquid and exploring their protein binding, anticancer and antipathogenic activities
( Elsevier B.V. , 2021 , Article)The interaction of nanoparticles with biological systems can provide useful information about their therapeutic applications. The aluminum nanoparticles (Al2O3 NPs) were synthesized by laser ablation technique and ... -
IBX/KI promoted synthesis of 2, 5-disubstituted 1, 3, 4-oxadiazoles
( Bentham Science Publishers B.V. , 2018 , Article)Background: Oxadiazoles are privileged scaffolds in different areas of medicinal, pesticidal, polymer and material science. They act as anticancer, benzodiazepine receptor agonists, antimicrobial, analgesic, diuretic and ... -
Novel paclitaxel formulations solubilized by parenteral nutrition nanoemulsions for application against glioma cell lines
( Elsevier, Ltd , 2016 , Article)The aim of this study is to investigate using nanoemulsion formulations as drug-delivery vehicles of paclitaxel (PX), a poor water-soluble anticancer drug. Two commercially available nanoemulsion fat formulations (Clinoleic ... -
Pharmacological and antioxidant activities of rhus coriaria l. (sumac)
( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Rhus coriaria L. (Anacardiaceae), commonly known as sumac, is a commonly used spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, sumac has been used in ... -
The Role of p90 Ribosomal S6 Kinase (RSK) in Tyrosine Kinase Inhibitor (TKI)-Induced Cardiotoxicity
( Springer , 2023 , Article Review)Targeted therapy, such as tyrosine kinase inhibitors (TKIs), has been approved to manage various cancer types. However, TKI-induced cardiotoxicity is a limiting factor for their use. This issue has raised the need for ... -
Structure-activity relationship investigation of methoxy substitution on anticancer pyrimido[4,5-c]quinolin-1(2H)-ones
(2013 , Article)Pyrimido[4,5-c]quinolin-1(2H)-one derivatives were shown to exert interesting biological activities including anticancer, antimicrobial, and cardiovascular. Substitution with methoxy groups played a crucial role in the ... -
Studies of the precipitation pattern of paclitaxel in intravenous infusions and rat plasma using laser nephelometry
( Taylor and Francis Ltd , 2018 , Article)Cremophor EL (CrEL) is commonly used to solubilize paclitaxel (Ptx); a widely established anticancer agent used against many types of cancer. Using laser-based microplate nephelometry, in this work we assessed the precipitation ... -
Synthesis and cytotoxic activity of MOM-ether analogs of isosteviol
( Elsevier Ltd. , 2014 , Article)Lung cancer is one of the most common malignancies worldwide. In this Letter, novel MOM-ether analogs of isosteviol were designed and synthesized to be tested for anticancer activities against H1299 lung cancer cell lines. ... -
Synthesis, immunomodulation and cytotoxic effects of vanadium (IV) complexes
( Bentham Science Publishers B.V. , 2014 , Article)Vanadium is known to exhibit several bioactivities and shows potential as a pharmaceutical drug. The current studies were conducted with the goal of synthesizing a new generation of oxovanadium(IV) complexes, investigating ... -
Testing the Anticancer Effect of Matcha Using Zebrafish as an Animal Model
(2023 , Master Thesis)Cancer is the second leading cause of death worldwide. Triple-negative breast cancer (TNBC) patients show the poorest prognosis and survival and the highest metastasis prevalence among all breast cancer subtypes. Matcha ... -
Thermodynamic and anticancer properties of inorganic zinc oxide nanoparticles synthesized through co-precipitation method
( Elsevier B.V. , 2021 , Article)In this paper, inorganic zinc oxide nanoparticles (ZnO NPs) were synthesized through co-precipitation method and after evaluating their physicochemical properties by using TEM and XRD techniques, the bio-thermodynamic and ...