Synthesis of some new oximes, thiocarbamates, pyrazolyloxy, isoxazolyloxy, Pyrmid yloxy and pyridyloxy quinolines

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Synthesis of some new oximes, thiocarbamates, pyrazolyloxy, isoxazolyloxy, Pyrmid yloxy and pyridyloxy quinolines

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Title: Synthesis of some new oximes, thiocarbamates, pyrazolyloxy, isoxazolyloxy, Pyrmid yloxy and pyridyloxy quinolines
Author: Abdel Hafez, Ali A. [علي عبد الحافظ]
Abstract: The reaction of 1 or its corresponding chalcones 3a-c with hydroxylamine in boiling pyridine gave the oximes 2 or 5a-c respectively in almost quantitative yield. When both 2 and 5a-c were reacted with phenylisothiocyanate, the corresponding thiocarbamates 4 and 6a-c were achieved. A new series of pyrazolyloxy 7a-f, isoxazolyloxy 8a-c, pyrimidyloxy 9a-f and pyridyloxy 10a,b quinolines were obtained from the reaction of 3a-c with hydrazines, hydroxylamine, urea, thiourea and malononitrile respectively. The in vitro antibacterial and antifungal activity were screened for all the compounds prepared, some of the compounds tested showed interesting results.يتفاعل مركب 5 - مورفو.
URI: http://hdl.handle.net/10576/10155
Date: 1994

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