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السجلات المعروضة 827 -- 846 من 1261
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Obesity Paradox among Heart Failure with Reduced Ejection Fraction Patients: A Retrospective Cohort Study
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Background and Objectives: There is consensus on the negative effects of obesity on the development of heart failure. However, several studies have suggested that obesity may have paradoxical survival benefits in heart ... -
Obesity-induced changes in kidney mitochondria and endoplasmic reticulum in the presence or absence of leptin
( American Physiological Society , 2015 , Article)We investigated obesity-induced changes in kidney lipid accumulation, mitochondrial function, and endoplasmic reticulum (ER) stress in the absence of hypertension, and the potential role of leptin in modulating these ... -
Objective structured clinical examination for pharmacy students in Qatar: cultural and contextual barriers to assessment.
( World Health Organization , 2016 , Article)This study aimed to evaluate the feasibility and psychometric defensibility of implementing a comprehensive objective structured clinical examination (OSCE) on the complete pharmacy programme for pharmacy students in a ... -
Obstructive sleep apnea: Management considerations in psychiatric patients
( Dove Press , 2015 , Article)Psychiatric disorders and obstructive sleep apnea (OSA) are often comorbid. However, there is limited information on the impact of psychotropic medications on OSA symptoms, on how to manage psychiatric pharmacotherapy in ... -
Online Pharmacies Selling Prescription Drugs: Systematic Review.
( MDPI , 2022 , Article)The patronage of online pharmacies is rapidly growing, driven by the convenience and cheaper costs of purchasing prescription drugs electronically, especially under the lockdown situation. However, there are issues regarding ... -
Open-label study of absorption and clearance of 1% voriconazole eye drops
( American Society for Microbiology , 2016 , Article)Twenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous ... -
Opinions and experiences on the provision of care to people with mental illnesses: a qualitative study with Doctor of Pharmacy graduates after a rotation in psychiatry.
( Springer Nature , 2023 , Article)Pharmacists are vital to optimizing therapy of people with mental illnesses. Limited knowledge, lack of confidence, and mental health-related stigma can lead to pharmacists' reluctance in the provision of pharmaceutical ... -
Optimizing assessors’ mental workload in rater-based assessment: a critical narrative review
( Bohn Stafleu van Loghum , 2019 , Article Review)Introduction Rater-based assessment has resulted in high cognitive demands for assessors within the education of health professionals. Rating quality may be influenced by the mental workload required of assessors to ... -
Optimizing polypharmacy management in the elderly: a comprehensive European benchmarking survey and the development of an innovative online benchmarking application
( Frontiers Media , 2023 , Article)Background: Polypharmacy, defined as the simultaneous use of multiple medications by a patient, is a worldwide problem of rising prevalence. Paving the way for drug interactions, adverse drug reactions and non-adherence, ... -
Oral PTCTS (Particulated Transialidase) Removes Serum Microparticles and Decreases Inflammation in Atherosclerotic Plaques of Rabbits
( Scientific Research Publishing , 2015 , Article)Background: Previous studies showed that atherosclerotic plaque vulnerability was related with microparticles (MPs)-vesicles larger than 100 nm, which released MMP9 collagenase. In our pre- vious study, intramuscular ... -
Orally Administered Amphotericin B Nanoformulations: Physical Properties of Nanoparticle Carriers on Bioavailability and Clinical Relevance
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Amphotericin B is an effective polyene antifungal considered as a “gold standard” in the management of fungal infections. Currently, it is administered mainly by IV due to poor aqueous solubility, which precludes its ... -
Osmotic-driven release of papaverine hydrochloride from novel poly(decane-co-tricarballylate) elastomeric matrices
( Newlands Press Ltd , 2010 , Article)Background: We have recently reported on the synthesis, characterization and biocompatibility of a novel family of visible-light photocrosslinked poly(diol-co-tricarballylate) elastomers intended for use in drug delivery ... -
Outcomes of patient education practices to optimize the safe use of lithium: A literature review
( Allen Press , 2018 , Article)Introduction: Lithium is commonly used to treat various psychiatric disorders and is particularly effective in the maintenance phase of bipolar disorder. Unfortunately, this drug has a narrow therapeutic index and, if not ... -
Overcoming pitfalls: Results from a mandatory peer review process for written examinations
( Elsevier Inc. , 2018 , Article)Problem description: Written assessments are essential components of higher education practices. However, faculty members encounter common pitfalls when designing questions intended to evaluate student-learning outcomes. ... -
Overview of Tissue Engineering and Drug Delivery Applications of Reactive Electrospinning and Crosslinking Techniques of Polymeric Nanofibers with Highlights on Their Biocompatibility Testing and Regulatory Aspects
(2024 , Article Review)Traditional electrospinning is a promising technique for fabricating nanofibers for tissue engineering and drug delivery applications. The method is highly efficient in producing nanofibers with morphology and porosity ... -
p90 ribosomal S6 kinase: a potential therapeutic target in lung cancer
( BioMed Central , 2016 , Article)A global survey of cancer has shown that lung cancer is the most common cause of the new cancer cases and cancer deaths in men worldwide. The mortality from lung cancer is more than the combined mortality from breast, ... -
Paclitaxel-loaded micro or nano transfersome formulation into novel tablets for pulmonary drug delivery via nebulization
( Elsevier , 2020 , Article)A simplistic approach was adopted to manufacture novel paclitaxel (PTX) loaded protransfersome tablet formulations for pulmonary drug delivery. The large surface area offered by the pulmonary system acts as a desirable ... -
Paclitaxel/methotrexate co-loaded PLGA nanoparticles in glioblastoma treatment: Formulation development and in vitro antitumor activity evaluation
( Elsevier , 2020 , Article)AimThe aim of this study was to improve the therapeutic index of chemotherapeutic drugs on glioblastoma cells through an improved co-drug delivery system. Materials and methodsMethotrexate (MTX) and paclitaxel (PTX) were ... -
Paradoxical Effect of Nonalcoholic Red Wine Polyphenol Extract, Provinols™, in the Regulation of Cyclooxygenases in Vessels from Zucker Fatty Rats (fa/fa)
( Hindawi Publishing Corporation , 2017 , Article)The aim of this work was to study the vascular effects of dietary supplementation of a nonalcoholic red wine polyphenol extract, Provinols, in Zucker fatty (ZF) obese rats. ZF or lean rats received diet supplemented or not ...