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Effect of Pharmacogenetic-Based Decision Support Tools in Improving Depression Outcomes: A Systematic Review
(
Qatar University Press
, 2021 , Poster)
Introduction: Evidence supporting pharmacogenetic (PGX) tests utility in depression is scarce. The main objectives of this study were to summarize, update, and assess the quality of the available evidence regarding PGX ...
Trends of use of SGLT2 inhibitors in Qatar
(
Qatar University Press
, 2021 , Poster)
Background: Type 2 diabetes mellitus (T2DM) represents a growing health challenge in Qatar and worldwide. T2DM is associated with a high risk of cardiovascular (CV) morbidity and mortality, and progression of renal disease. ...
Survey Among Healthcare Professionals On The Implications Of Pharmacogenetics And Its Limitations
(
Hamad bin Khalifa University Press (HBKU Press)
, 2014 , Conference Paper)
Pharmacists are expected to play an important role in applying pharmacogenetic discoveries to patient care. Despite the increased attention to genetic research in Qatar, clinicians' attitude towards pharmacogenetics' ...
Vancomycin therapeutic drug monitoring service quality indices and clinical effectiveness outcomes: A retrospective cohort and clinical audit
(
Blackwell Publishing Ltd
, 2020 , Article)
Introduction: Vancomycin is commonly used for the treatment of complicated infections caused by methicillin-resistant Staphylococcus aureus. The impact of vancomycin therapeutic drug monitoring (TDM) quality indices on ...
Effect of CYP2C19 genetic variants on bleeding and major adverse cardiovascular events in a cohort of Arab patients undergoing percutaneous coronary intervention and stent implantation
(
Lippincott Williams and Wilkins
, 2022 , Article)
Introduction One-third of patients have clopidogrel resistance that may lead to major adverse cardiac events (MACEs). By contrast, it was found that some clopidogrel-treated patients have hyperresponsive platelets that are ...
A 5-year trend in the use of sodium-glucose co-transporter 2 inhibitors and other oral antidiabetic drugs in a Middle Eastern country
(
Springer Science and Business Media Deutschland GmbH
, 2022 , Article)
Background: Sodium glucose co-transporter 2 inhibitors (SGLT2is) are a novel class of oral antidiabetic drugs. To date, there are no pharmacoepidemiologic studies investigating the pattern of use of SGLT2is compared to ...
Genomewide association analysis of warfarin dose requirements in Middle Eastern and North African populations
(
Wiley-Blackwell
, 2022 , Article)
To date, there has been no genomewide association study (GWAS) from the Middle East and North African (MENA) region to identify genetic variants associated with warfarin dose variability using this approach. In this study, ...
Direct oral anticoagulants are effective and safe in the treatment of venous thromboembolism and atrial fibrillation in morbidly obese patients
(
Springer
, 2020 , Other)
There has always been unresolved uncertainty regarding the therapeutic utility of direct oral anticoagulants (DOACs) in morbidly obese patients (BMI > 40 kg/m2 or weight > 120 kg) with clinical indications for anticoagulant's ...
Warfarin dosing strategies evolution and its progress in the era of precision medicine, a narrative review
(
Springer
, 2022 , Article Review)
Background For decades, vitamin K antagonists and specifically warfarin, have been the sole agents used orally to manage thromboembolic conditions, including stroke and venous thromboembolism (VTE). Several factors lead ...
Comparative effectiveness and safety of direct oral anticoagulants compared to warfarin in morbidly obese patients with acute venous thromboembolism: systematic review and a meta-analysis
(
Springer
, 2021 , Article)
Direct oral anticoagulant (DOAC) agents are becoming the anticoagulation strategy of choice. However, their use in the treatment of acute venous thromboembolism (VTE) in morbidly obese patients (bodyweight of > 120 kg or ...