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AuthorAshiq, Uzma
AuthorJamal, Rifat Ara
AuthorMesaik, Mohammad Ahmed
AuthorMahroof-Tahir, Muhammad
AuthorShahid, Saba
AuthorKhan, Khalid Mohammed
Available date2016-06-21T13:29:05Z
Publication Date2014
Publication NameMedicinal Chemistry
CitationAshiq, U., Jamal, R.A., Mesaik, M.A., Mahroof-Tahir, M., Shahid, S., Khan, K.M. "Synthesis, immunomodulation and cytotoxic effects of vanadium (IV) complexes" (2014) Medicinal Chemistry, 10 (3), pp. 287-299.
ISSN1573-4064
URIhttp://dx.doi.org/10.2174/15734064113099990033
URIhttp://hdl.handle.net/10576/4627
AbstractVanadium is known to exhibit several bioactivities and shows potential as a pharmaceutical drug. The current studies were conducted with the goal of synthesizing a new generation of oxovanadium(IV) complexes, investigating their effects on cancer cell proliferation and their immunomodulatory properties, and predicting possible structure activity relationships. The elucidation of the structures of the synthesized complexes was achieved using elemental analysis, conductivity measurements, magnetic property measurements, and IR and electronic spectroscopies. These studies suggest that the synthesized complexes have a binuclear structure. All of the complexes were evaluated on different cancer cell lines, including HeLa, PC-3, and C33A, and on the normal 3T3 fibroblast cells. Some of the compounds exhibited prominent inhibitory activities on the cervical cancer cell lines and the prostate cancer PC-3 cells. The immunomodulatory activity of the vanadium compounds was evaluated on human phagocytes for ROS (reactive oxygen species) production using luminol- and lucigenin-based chemiluminescence assays. No potent effect was exerted by the majority of the tested compounds on whole blood oxidative burst activity. A study of human T-cells proliferation in vitro on vanadium complexes was also conducted. The majority of the compounds were observed to exhibit potent inhibitory effects. The superoxide, nitric oxide and DPPH (2,2-diphenyl-1- picrylhydrazyl) radical scavenging properties were also determined.
Languageen
PublisherBentham Science Publishers B.V.
SubjectAnticancer
SubjectChemiluminescence
SubjectDPPH
SubjectImmunomodulation
SubjectSuperoxide
SubjectVanadium(IV)
Subject3T3 Cells
SubjectAntineoplastic Agents Cell Line, Tumor
SubjectCell Proliferation
SubjectCytotoxins
SubjectDose-Response Relationship, Drug
TitleSynthesis, immunomodulation and cytotoxic effects of vanadium (IV) complexes
TypeArticle
Pagination287-299
Issue Number3
Volume Number10


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