Biomedical Sciences
Recent Submissions
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Computational design of anti-cancer peptides tailored to target specific tumor markers
( Springer Nature , 2024 , Article)Anti-cancer peptides (ACPs) are short peptides known for their ability to inhibit tumor cell proliferation, migration, and the formation of tumor blood vessels. In this study, we designed ACPs to target receptors often ... -
Immune stimulatory effect of Nigella sativa in healthy animal models: A systematic review and meta-analysis
( Elsevier Ltd , 2024 , Article)The immune-modulatory effects of black seeds (Nigella sativa seeds, NSS) are well documented, but the overall in vivo impact of this important natural medicinal product on immune system function has yet to be established. ... -
Laboratory testing efficiency during the COVID pandemic: Findings from the Primary Health Care Corporation laboratories in the State of Qatar
( Elsevier Ltd , 2024 , Article)Background Little is known about how the COVID-19 pandemic altered laboratory testing efficiency in the State of Qatar. The aim of this study was to assess laboratory testing efficiency with respect to the total number ... -
The genetic basis and the diagnostic yield of genetic testing related to nonsyndromic hearing loss in Qatar
( Springer Nature , 2024 , Article)Hearing loss is the most predominant sensory defect occurring in pediatrics, of which, 66% cases are attributed to genetic factors. The prevalence of hereditary hearing loss increases in consanguineous populations, and the ... -
The Effects of Spirulina Supplementation on Cardiometabolic Risk Factors: A Narrative Review
( Taylor & Francis , 2024 , Article)Spirulina (Arthrospira platensis) is a cyanobacterium associated with multiple health benefits. Cardiometabolic diseases such as cardiovascular disease, nonalcoholic fatty liver disease, and diabetes are prevalent yet ... -
The Interaction Between Body Mass Index Genetic Risk Score and Dietary Intake on Weight Status: A Systematic Review
( Dove Medical Press Ltd , 2024 , Article Review)Background: The escalating global obesity epidemic and the emergence of personalized medicine strategies point to the pressing need to investigate the interplay between genetic risk scores (GRSs), dietary intake, and their ... -
Impact of the MIF -173G/C variant on cardiovascular disease risk: a meta-analysis of 9,047 participants
( Frontiers Media SA , 2024 , Article Review)Introduction: Many factors contribute to the risk of cardiovascular disease (CVD), an umbrella term for several different heart diseases, including inflammation. Macrophage migration inhibitory factor (MIF) is an important ... -
Exploring the natural products chemical space to abrogate the F3L-dsRNA interface of monkeypox virus to enhance the immune responses using molecular screening and free energy calculations
( Frontiers Media SA , 2023 , Article)Amid the ongoing monkeypox outbreak, there is an urgent need for the rapid development of effective therapeutic interventions capable of countering the immune evasion mechanisms employed by the monkeypox virus (MPXV). The ... -
Uncommon presentation of complicated internal hernia through the appendices epiploicae ring of adhesion: a clinical case study
( Frontiers Media , 2024 , Article)Background: Internal hernias are infrequent, yet serious, medical conditions with potentially severe consequences. An internal hernia resulting from an Appendices epiploicae (AE) ring is an especially rare cause, with a ... -
Breaking Barriers: The Promise and Challenges of Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article Review)Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with pronounced immunogenicity, exhibiting rapid proliferation and immune cell infiltration into the tumor microenvironment. TNBC’s heterogeneity poses ... -
An optimized CT-dense agent perfusion and micro-CT imaging protocol for chick embryo developmental stages.
( BMC , 2024 , Article)Compared to classical techniques of morphological analysis, micro-CT (μ-CT) has become an effective approach allowing rapid screening of morphological changes. In the present work, we aimed to provide an optimized micro-CT ... -
Trilayer composite scaffold for urethral reconstruction: in vitro evaluation of mechanical, biological, and angiogenic properties
( IOP Publishing , 2024 , Article)Regeneration of damaged urethral tissue remains a major challenge in the field of lower urinary tract reconstruction. To address this issue, various synthetic and natural biodegradable biomaterials are currently being ... -
In vivo testing of novel nitric oxide-releasing nanoparticles for alleviating heart failure using the zebrafish embryo model
( Elsevier , 2024 , Article)Heart failure (HF) is a multifactorial, heterogeneous systemic disease that is considered one of the leading causes of death and morbidity worldwide. It is well-known that endothelial dysfunction (ED) plays an important ... -
The Association between Lifestyle Factors and COVID-19: Findings from Qatar Biobank.
( MDPI , 2024 , Article)Coronavirus Disease 2019 (COVID-19) manifestations range from mild to severe life-threatening symptoms, including death. COVID-19 susceptibility has been associated with various factors, but studies in Qatar are limited. ... -
In vitro and in vivo efficacy of a novel quinuclidinone derivative against breast cancer
( International Institute of Anticancer Research , 2014 , Other)Previously, our laboratory reported on novel quinuclidinone derivatives that cause cytotoxicity in human non-small lung carcinoma epithelial cells null for p53 (H1299). The current study aims to investigate the effect of ... -
Biological and biomedical functions of Penta-O-galloyl-D-glucose and its derivatives
( Springer Nature , 2014 , Other)Penta-O-galloyl-D-glucose (PGG) is a simple hydrolysable tannin in plants. PGG exists in two anomeric forms, α-PGG and β-PGG. While β-PGG can be found in a wide variety of plants, α-PGG is rather rare in nature. Numerous ... -
Glucose- and triglyceride-lowering dietary penta-O-galloyl-α-D-glucose reduces expression of PPARγ and C/EBPα, induces p21-Mediated G1 phase cell cycle arrest, and inhibits adipogenesis in 3T3-L1 preadipocytes
( Thieme , 2015 , Article)Plant polyphenols, such as hydrolysable tannins, are present in the human diet and known to exhibit anti-diabetic and anti-obesity activity. We previously reported that the representative hydrolysable tannin compound ... -
Novel thiosemicarbazides induced apoptosis in human MCF-7 breast cancer cells via JNK signaling
( Taylor & Francis , 2015 , Article)In this study, novel thiosemicarbazides and 1,3,4-oxadiazoles were synthesized and evaluated for their anticancer effects on human MCF-7 breast cancer cell lines. Among the synthesized derivatives studied, compound ... -
Metformin increases 3-hydroxy medium chain fatty acids in patients with type 2 diabetes: a cross-sectional pharmacometabolomic study
( Frontiers Media SA , 2024 , Article)Background: Metformin is a drug with a long history of providing benefits in diabetes management and beyond. The mechanisms of action of metformin are complex, and continue to be actively debated and investigated. The aim ... -
The effect of novel nitrogen-based chalcone analogs on colorectal cancer cells: Insight into the molecular pathways
( Elsevier , 2024 , Article)In colorectal cancer (CRC), aberrations in KRAS are associated with aggressive tumorigenesis and an overall low survival rate because of chemoresistance and adverse effects. Ergo, complementary, and integrative medicines ...