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AuthorHussein, Yasser H. A.
AuthorYoussry, Mohamed
Available date2018-04-29T11:12:24Z
Publication Date2018-04-27
Publication NameMaterials
Identifierhttp://dx.doi.org/10.3390/ma11050688
CitationHussein, Y.H.A.; Youssry, M. Polymeric Micelles of Biodegradable Diblock Copolymers: Enhanced Encapsulation of Hydrophobic Drugs. Materials 2018, 11, 688.
ISSN1996-1944
IdentifierArticle number: 688
URIhttp://hdl.handle.net/10576/6633
AbstractPolymeric micelles are potentially efficient in encapsulating and performing the controlled release of various hydrophobic drug molecules. Understanding the fundamental physicochemical properties behind drug–polymer systems in terms of interaction strength and compatibility, drug partition coefficient (preferential solubilization), micelle size, morphology, etc., encourages the formulation of polymeric nanocarriers with enhanced drug encapsulating capacity, prolonged circulation time, and stability in the human body. In this review, we systematically address some open issues which are considered to be obstacles inhibiting the commercial availability of polymer-based therapeutics, such as the enhancement of encapsulation capacity by finding better drug–polymer compatibility, the drug-release kinetics and mechanisms under chemical and mechanical conditions simulating to physiological conditions, and the role of preparation methods and solvents on the overall performance of micelles
Languageen
PublisherMDPI
Subjectdiblock copolymers
polymeric micelles
drug encapsulation
physicochemical properties
biodegradable
biocompatible copolymers
TitlePolymeric Micelles of Biodegradable Diblock Copolymers: Enhanced Encapsulation of Hydrophobic Drugs
TypeArticle Review
Pagination1-26
Issue Number5
Volume Number11
ESSN1996-1944
dc.accessType Open Access


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