Thermal and Optical Radiation Effects on LEH

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Thermal and Optical Radiation Effects on LEH

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Title: Thermal and Optical Radiation Effects on LEH
Author: Al Fahhad, Marwan. A. [مروان الفهد]
Abstract: Synthetic red blood cells known as LEH is a material that offers an excellent alternative to substitution blood since the chemical composition of the Oxy, LEH, is similar to that of the natural blood cells. Unfortunately, this alternative, like the natural blood, has a limited shelf life at room temperature due to thermal and/or solar (optical) radiations exposure. In this study experiments were run on LEH assays, with and without protection additives, to weigh up the effect of exposing LEH to thermal effect, using a digital controlled oven, and to optical radiations, using an appropriate apparatus to simulate the solar optical radiations. Constant evaluation of the acceptability of this artificial blood alternative was done with the help of an advanced computerized technique. The results of the experiment have shown that exposing LEH to thermal and optical radiations leads to a reduction of the concentration of the oxyhemoglobin and a heightened of the concentration of the methemoglobin. The rate of LEH degra dation in the two treatments was linked to the time in which they were exposed both to the thermal and optical radiations effects. Antioxidants, ascorbic acid and alfa-tocopherol were used in order to conserve and guard the prepared LEH from the degradation that happens to it due to the effects of both thermal and optical radiations.تصلح كريات الدم الحمراء المصنعة الصروفة باسم ل . ا. د. كبديل ممتاز فى عمليات نقل الدم ، وهى منافس جيد لنقل الأوكسجين ، تماما كما نغعل كريات الدم الحمراء الطبيعية،. ولكن لائرسف فان هذا البديل الصناعى يشبه الدم الطبيعى فى قصر مدة الحياة عندما يحفظ على الرف فى دوجة حرارة الغرفة العادية، وذلك نظرا لتأثره بالاشعاع الحرارى والضوئى . فى هذه الدراسة تم سكمل تحاليل حول عمل كريات الدم الحمراء المصنعة، مع وبدون اضافات للحماية .
URI: http://hdl.handle.net/10576/9862
Date: 2003

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