Browsing by Author "Pintus, Gianfranco"
Now showing items 1-20 of 28
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Activation of the Pro-Oxidant PKCβII-p66Shc Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Diabetic Patients with Critical Limb Ischemia
Vono, Rosa; Fuoco, Claudio; Testa, Stefano; Pirrò, Stefano; Maselli, Davide; McCollough, David Ferland; Sangalli, Elena; Pintus, Gianfranco; Giordo, Roberta; Finzi, Giovanna; Sessa, Fausto; Cardani, Rosanna; Gotti, Ambra; Losa, Sergio; Cesareni, Gianni; Rizzi, Roberto; Bearzi, Claudia; Cannata, Stefano; Spinetti, Gaia; Gargioli, Cesare; Madeddu, Paolo... more authors ... less authors ( American Diabetes Association , 2016 , Article)Critical limb ischemia (CLI), foot ulcers, former amputation and impaired regeneration are independent risk factors for limb amputation in diabetic subjects. The present work investigates whether and by which mechanism ... -
Cytoprotective, antioxidant, and anti-migratory activity of Pistacia lentiscus L. supercritical carbon dioxide extract on primary human endothelial cells
Giordo, Roberta; Cossu, Annalisa; Porcu, Maria Cristina; Cappuccinelli, Roberto; Biosa, Grazia; Sharifi-Rad, Javad; Pretti, Luca; Nasrallah, Gheyath K.; Pintus, Gianfranco; Posadino, Anna Maria... more authors ... less authors ( Taylor & Francis , 2022 , Article)Green chemistry is a useful tool for producing valuable chemicals from biomass. However, extracted compounds need to be tested for safety and efficacy before their use in humans. Here we investigate the chemical composition ... -
D-Dimer Concentrations and COVID-19 Severity: A Systematic Review and Meta-Analysis
Paliogiannis, Panagiotis; Mangoni, Arduino; Dettori, Paola; Nasrallah, Gheyath; Pintus, Gianfranco; Zinellu, Angelo... more authors ... less authors ( Frontiers Media , 2020 , Article Review)Coronavirus disease 2019 (COVID-19) is a recently described infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since late 2019, COVID-19 has rapidly spread in virtually all countries, ... -
Effect of Resveratrol on Pregnancy, Prenatal Complications and Pregnancy-Associated Structure Alterations.
Ramli, Iman; Posadino, Anna Maria; Giordo, Roberta; Fenu, Grazia; Fardoun, Manal; Iratni, Rabah; Eid, Ali H; Zayed, Hatem; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2023 , Article Review)Adverse pregnancy outcomes are considered significant health risks for pregnant women and their offspring during pregnancy and throughout their lifespan. These outcomes lead to a perturbated in-utero environment that impacts ... -
EndMT regulation by small RNAs in diabetes-associated fibrotic conditions: potential link with oxidative stress
Giordo, Roberta; Mohammed, Yusra; Allam, Hilda; Abusnana, Salah; Pappalardo, Lucia; Nasrallah, Gheyath; Mangoni, Arduino; Pintus, Gianfranco... more authors ... less authors ( Frontiers Media , 2021 , Article)Diabetes-associated complications, such as retinopathy, nephropathy, cardiomyopathy, and atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ dysfunction, disability, and increased mortality. ... -
Epac as a tractable therapeutic target
Hasan, Slika; Mansour, Hadi; Nasser, Suzanne A.; Shaito, Abdullah; Kobeissy, Firas; Orekhov, Alexander N.; Pintus, Gianfranco; Eid, Ali H.... more authors ... less authors ( Elsevier , 2023 , Article)In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the first signaling cascade discovered was the cAMP-protein kinase A (PKA) pathway. Since then, cAMP has received increasing ... -
Evaluation of Global Genomic DNA Methylation in Human Whole Blood by Capillary Electrophoresis UV Detection
Zinellu, Angelo; Sotgiu, Elisabetta; Assaretti, Stefano; Sotgia, Salvatore; Paliogiannis, Panagiotis; Pintus, Gianfranco; Mangoni, Arduino A.; Carru, Ciriaco... more authors ... less authors ( Hindawi Publishing Corporation , 2017 , Article)Alterations in global DNA methylation are implicated in various pathophysiological processes. The development of simple and quick, yet robust, methods to assess DNA methylation is required to facilitate its measurement and ... -
Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety
Shaito, Abdullah; Thuan, Duong Thi Bich; Phu, Hoa Thi; Nguyen, Thi Hieu Dung; Hasan, Hiba; Halabi, Sarah; Abdelhady, Samar; Nasrallah, Gheyath K.; Eid, Ali H.; Pintus, Gianfranco... more authors ... less authors ( Frontiers Media S.A. , 2020 , Article)Cardiovascular diseases (CVDs) are a significant health burden with an ever-increasing prevalence. They remain the leading causes of morbidity and mortality worldwide. The use of medicinal herbs continues to be an ... -
Herbal medicine for slowing aging and aging-associated conditions: Efficacy, mechanisms and safety
Phu, Hoa T.; Thuan, Duong T.B.; Nguyen, Thi H.D.; Posadino, Anna M.; Eid, Ali H.; Pintus, Gianfranco... more authors ... less authors ( Bentham , 2020 , Article)Aging and aging-associated diseases are issues with unsatisfactory answers in the medical field. Aging causes important physical changes which, even in the absence of the usual risk factors, render the cardiovascular system ... -
High-sensitive detection and quantitation of thyroid-stimulating hormone (TSH) from capillary/fingerstick and venepuncture whole-blood using fluorescence-based rapid lateral flow immunoassay (LFIA)
Samar, Shurbaji; Al Tamimi, Faleh; Al Ghwairi, Mahmoud M.; El Chaar, Dayana; Younes, Salma; Majdalawieh, Amin F.; Pintus, GianFranco; Al-Dewik, Nader; Nasrallah, Gheyath K.... more authors ... less authors ( Elsevier , 2023 , Article)BackgroundIn the last decade, point of care testing (POCT) such as lateral flow immunoassays (LFIA) were developed for rapid TSH measurement. Most of these TSH-LFIAs are designed for qualitative measurements (i.e., if TSH ... -
Identification of the Main Intermediate Precursor of l-Ergothioneine Biosynthesis in Human Biological Specimens
Sotgia, Salvatore; Mangoni, Arduino A.; Forteschi, Mauro; Murphy, Rhys B.; Elliot, David; Sotgiu, Elisabetta; Pintus, Gianfranco; Carru, Ciriaco; Zinellu, Angelo... more authors ... less authors ( MDPI AG , 2016 , Article)A capillary electrophoresis coupled to tandem mass spectrometry (CE–MS/MS) has been used to make a qualitative determination of hercynine—the main precursor of l-ergothioneine biosynthesis—in some key human biological ... -
Impaired Liver Size and Compromised Neurobehavioral Activity are Elicited by Chitosan Nanoparticles in the Zebrafish Embryo Model
Abou-Saleh, Haissam; Younes, Nadin; Rasool, Kashif; Younis, Manaf H.; Prieto, Rafael M.; Yassine, Hadi M.; Mahmoud, Khaled A.; Pintus, Gianfranco; Nasrallah, Gheyath K.... more authors ... less authors ( MDPI , 2019 , Article)The use of chitosan nanoparticles (ChNPs) in various biological and environmental applications is attracting great interest. However, potential side effects related to ChNP toxicity remain the major limitation hampering ... -
Implications and theragnostic potentials of circular RNAs in rheumatic diseases
Alaa Ahmed, Abbas; Abdulkader, Hadil Adnan; Giordo, Roberta; Ashour, Hossam M.; Erre, Gian Luca; Pintus, Gianfranco; Zayed, Hatem... more authors ... less authors ( Elsevier , 2023 , Article Review)Circular RNAs (circRNAs), a class of non-coding RNAs (ncRNAs), are highly stable and ubiquitous molecules that exhibit tissue-specific expression. Accumulating evidence has shown that aberrant expression of circRNAs can ... -
Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells
Ippolito, Luigi; Marini, Alberto; Cavallini, Lorenzo; Morandi, Andrea; Pietrovito, Laura; Pintus, Gianfranco; Giannoni, Elisa; Schrader, Thomas; Puhr, Martin; Chiarugi, Paola; Taddei, Maria Letizia... more authors ... less authors ( Impact Journals , 2016 , Article)Drug resistance of cancer cells is recognized as the primary cause of failure of chemotherapeutic treatment in most human cancers. Growing evidences support the idea that deregulated cellular metabolism is linked to such ... -
microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative review
Roberta, Giordo; Ahmadi, Fatemeh Abdullah M.; Husaini, Nedal Al; Al-Nuaimi, Noora Rashid A.M.; Ahmad, Salma M.S.; Pintus, Gianfranco; Zayed, Hatem... more authors ... less authors ( Elsevier , 2024 , Article)Non-coding RNAs (ncRNAs) are a diverse group of functional RNA molecules that lack the ability to code for proteins. Despite missing this traditional role, ncRNAs have emerged as crucial regulators of various biological ... -
NADPH-derived ROS generation drives fibrosis and endothelial-to-mesenchymal transition in systemic sclerosis: Potential cross talk with circulating miRNAs
Posadino, Anna Maria; Erre, Gian Luca; Cossu, Annalisa; Emanueli, Costanza; Eid, Ali H.; Zinellu, Angelo; Pintus, Gianfranco; Giordo, Roberta... more authors ... less authors ( Walter de Gruyter , 2022 , Article)Systemic sclerosis (SSc) is an immune disorder characterized by diffuse fibrosis and vascular abnormalities of the affected organs. Although the etiopathology of this disease is largely unknown, endothelial damage and ... -
Nano-targeting vascular remodeling in cancer: Recent developments and future directions
Roberta, Giordo; Wehbe, Zena; Paliogiannis, Panagiotis; Eid, Ali H.; Mangoni, Arduino A.; Pintus, Gianfranco... more authors ... less authors ( Elsevier , 2022 , Article Review)Tumor growth and progression are strictly dependent on the adequate blood supply of oxygen and nutrients. The formation of new blood vessels and vascular networks is essential to ensure this demand. Blood vessels also ... -
Non-coding RNAs as biomarkers of myocardial infarction
Almaghrbi, Heba; Giordo, Roberta; Pintus, Gianfranco; Zayed, Hatem ( Elsevier , 2023 , Article)Non-coding RNAs (ncRNAs) encompass a family of ubiquitous RNA molecules that lack protein-coding potential and have tissue-specific expression. A significant body of evidence indicates that ncRNA's aberrant expression plays ... -
The pharmaco-epigenetics of hypertension: a focus on microRNA
Yaacoub, Serge; Boudaka, Ammar; AlKhatib, Ali; Pintus, Gianfranco; Sahebkar, Amirhossein; Kobeissy, Firas; Eid, Ali H.... more authors ... less authors ( Springer Nature , 2024 , Article)Hypertension is a major harbinger of cardiovascular morbidity and mortality. It predisposes to higher rates of myocardial infarction, chronic kidney failure, stroke, and heart failure than most other risk factors. By 2025, ... -
Pharmacological and antioxidant activities of rhus coriaria l. (sumac)
Alsamri, Halima; Athamneh, Khawlah; Pintus, Gianfranco; Eid, Ali H.; Iratni, Rabah ( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Rhus coriaria L. (Anacardiaceae), commonly known as sumac, is a commonly used spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, sumac has been used in ...