Browsing by Author "Moltrasio, Chiara"
Now showing items 1-12 of 12
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25-Hydroxyvitamin D serum levels inversely correlate to disease severity and serum C-reactive protein levels in patients with hidradenitis suppurativa
Moltrasio, Chiara; Tricarico, Paola Maura; Genovese, Giovanni; Gratton, Rossella; Marzano, Angelo V.; Crovella, Sergio... more authors ... less authors ( Wiley , 2021 , Other)Vitamin D exerts functions in skin physiology by modulating keratinocyte proliferation and different immunoregulatory processes.1 In several dermatoses, vitamin D correlates to disease severity and is significantly lower ... -
Autoinflammation in Syndromic Hidradenitis Suppurativa: The Role of AIM2.
Moltrasio, Chiara; Cagliani, Rachele; Sironi, Manuela; Clerici, Mario; Pontremoli, Chiara; Maronese, Carlo Alberto; Tricarico, Paola Maura; Crovella, Sergio; Marzano, Angelo Valerio... more authors ... less authors ( MDPI , 2023 , Report)AIM2 is a key cytoplasmatic pathogen-sensor that detects foreign DNA from viruses and bacteria; it can also recognize damaged or anomalous presence of DNA, promoting inflammasome assembly and activation with the secretion ... -
Different molecular pathways are disrupted in Pyoderma gangrenosum patients and are associated with the severity of the disease.
Moura, Ronald Rodrigues; Brandão, Lucas; Moltrasio, Chiara; Agrelli, Almerinda; Tricarico, Paola Maura; Maronese, Carlo Alberto; Crovella, Sergio; Marzano, Angelo Valerio... more authors ... less authors ( Nature Research , 2023 , Article)Pyoderma gangrenosum (PG) is a rare inflammatory skin disease classified within the spectrum of neutrophilic dermatoses. The pathophysiology of PG is yet incompletely understood but a prominent role of genetics facilitating ... -
Hidradenitis Suppurativa: A Perspective on Genetic Factors Involved in the Disease.
Moltrasio, Chiara; Tricarico, Paola Maura; Romagnuolo, Maurizio; Marzano, Angelo Valerio; Crovella, Sergio ( MDPI , 2022 , Article)Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease of the pilosebaceous unit, clinically consisting of painful nodules, abscesses, and sinus tracts mostly in, but not limited to, intertriginous skin areas. ... -
Holistic health record for Hidradenitis suppurativa patients.
Tricarico, Paola Maura; Moltrasio, Chiara; Gradišek, Anton; Marzano, Angelo V; Flacher, Vincent; Boufenghour, Wacym; von Stebut, Esther; Schmuth, Matthias; Jaschke, Wolfram; Gams, Matjaž; Boniotto, Michele; Crovella, Sergio... more authors ... less authors ( Nature Research , 2022 , Article)Hidradenitis suppurativa (HS) is a recurrent inflammatory skin disease with a complex etiopathogenesis whose treatment poses a challenge in the clinical practice. Here, we present a novel integrated pipeline produced by ... -
Paraviral cutaneous manifestations associated to SARS-CoV-2 Omicron variant
Zupin, Luisa; Moltrasio, Chiara; Tricarico, Paola Maura; Del Vecchio, Cecilia; Fontana, Francesco; Marzano, Angelo Valerio; Crovella, Sergio... more authors ... less authors ( Taylor and Francis Group , 2022 , Article)Background: The spreading of the SARS-CoV-2 Omicron variant is probably due to its increased transmissibility and ability to escape from neutralising antibodies. Cutaneous manifestations have been reported after infection ... -
Pleiotropic role of notch signaling in human skin diseases
Gratton, Rossella; Tricarico, Paola Maura; Moltrasio, Chiara; de Oliveira, Ana Sofia Lima Estevão; Brandão, Lucas; Marzano, Angelo Valerio; Zupin, Luisa; Crovella, Sergio... more authors ... less authors ( MDPI , 2020 , Article Review)Notch signaling orchestrates the regulation of cell proliferation, differentiation, migration and apoptosis of epidermal cells by strictly interacting with other cellular pathways. Any disruption of Notch signaling, either ... -
A rare loss-of-function genetic mutation suggest a role of dermcidin deficiency in hidradenitis suppurativa pathogenesis
Tricarico, Paola Maura; Gratton, Rossella; Santos-Silva, Carlos André dos; Moura, Ronald Rodrigues de; Ura, Blendi; Sommella, Eduardo; Campiglia, Pietro; Del Vecchio, Cecilia; Moltrasio, Chiara; Berti, Irene; D’Adamo, Adamo Pio; Elsherbini, Ahmed M.A.; Staudenmaier, Lena; Chersi, Karin; Boniotto, Michele; Krismer, Bernhard; Schittek, Birgit; Crovella, Sergio... more authors ... less authors ( Frontiers Media , 2022 , Article)Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a multifactorial aetiology that involves a strict interplay between genetic factors, immune dysregulation and lifestyle. Familial forms represent ... -
SARS-CoV-2 does not replicate in HaCaT spontaneously immortalized human keratinocytes: implications for the pathogenesis of COVID-19-associated skin manifestations
Zupin, Luisa; Moltrasio, Chiara; Genovese, Giovanni; Milani, Margherita; Fontana, Francesco; Ruscio, Maurizio; Valerio Marzano, Angelo; Crovella, Sergio... more authors ... less authors ( John Libbey Eurotext , 2022 , Article)Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-related cutaneous manifestations have been reported [1], however, the direct or indirect role of SARS-CoV-2 infection in their pathophysiology is still debated ... -
Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling
de Oliveira, Ana Sofia Lima Estevao; Bloise, Giovanna; Moltrasio, Chiara; Coelho, Antonio; Agrelli, Almerinda; Moura, Ronald; Tricarico, Paola Maura; Jamain, Stéphane; Marzano, Angelo Valerio; Crovella, Sergio; Cavalcanti Brandão, Lucas André... more authors ... less authors ( MDPI , 2022 , Article)Hidradenitis suppurativa (HS) is an inflammatory skin condition clinically characterized by recurrent painful deep-seated nodules, abscesses, and sinus tracks in areas bearing apocrine glands, such as axillae, breasts, ... -
Variant Enrichment Analysis to Explore Pathways Functionality in Complex Autoinflammatory Skin Disorders through Whole Exome Sequencing Analysis.
Brandão, Lucas André Cavalcanti; Moura, Ronald Rodrigues de; Marzano, Angelo Valerio; Moltrasio, Chiara; Tricarico, Paola Maura; Crovella, Sergio... more authors ... less authors ( MDPI , 2022 , Article)The challenge of unravelling the molecular basis of multifactorial disorders nowadays cannot rely just on association studies searching for potential causative variants shared by groups of patients and not present in healthy ... -
Whole-Exome Sequencing in 10 Unrelated Patients with Syndromic Hidradenitis Suppurativa: A Preliminary Step for a Genotype-Phenotype Correlation.
Marzano, Angelo Valerio; Genovese, Giovanni; Moltrasio, Chiara; Tricarico, Paola Maura; Gratton, Rossella; Piaserico, Stefano; Garcovich, Simone; Boniotto, Michele; Brandão, Lucas; Moura, Ronald; Crovella, Sergio... more authors ... less authors ( Karger Publishers , 2022 , Article)The genetics of syndromic hidradenitis suppurativa (HS), an immune-mediated condition associated with systemic comorbidities such as inflammatory bowel diseases and arthritis, has not been completely elucidated. To describe ...