SARS-CoV-2 does not replicate in HaCaT spontaneously immortalized human keratinocytes: implications for the pathogenesis of COVID-19-associated skin manifestations
Valerio Marzano, Angelo
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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-related cutaneous manifestations have been reported , however, the direct or indirect role of SARS-CoV-2 infection in their pathophysiology is still debated . Angiotensin-converting enzyme 2 (ACE2) is highly expressed in keratinocytes, suggesting percutaneous transmission as a potential route for SARS-CoV-2 infection . Currently, the susceptibility of keratinocytes to SARS-CoV-2 has not been investigated. Thus, two HaCaT spontaneously .