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Now showing items 17396-17415 of 52941
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Molecular correlates of immune cytolytic subgroups in colorectal cancer by integrated genomics analysis
( Oxford University Press , 2021 , Article)Although immune checkpoint inhibition (ICI) has shown promising results in metastatic dMMR/MSI-H colorectal cancer (CRC), the majority of pMMR/MSS patients do not respond to such therapies. To systematically evaluate the ... -
Molecular Design of Novel Chemicals for Iron Sulfide Scale Removal
( Hindawi Limited , 2021 , Article)Scale deposition is a pertinent challenge in the oil and gas industry. Scales formed from iron sulfide are one of the troublous scales, particularly pyrite. Moreover, the use of biodegradable environmentally friendly ... -
Molecular Design Strategy for Ordered Mesoporous Stoichiometric Metal Oxide
( Wiley-VCH Verlag , 2019 , Article)A molecular design strategy is used to construct ordered mesoporous Ti3+-doped Li4Ti5O12 nanocrystal frameworks (OM-Ti3+-Li4Ti5O12) by the stoichiometric cationic coordination assembly process. Ti4+/Li+-citrate chelate is ... -
Molecular detection of SARS-CoV-2 from indoor air samples in environmental monitoring needs adequate temporal coverage and infectivity assessment
( Elsevier , 2021 , Article)The relevance of airborne exposure to SARS-CoV-2 in indoor environments is a matter of research and debate, with special importance for healthcare low-risk settings. Experimental approaches to the bioaerosol sampling are ... -
Molecular Dynamic Simulations of Fibrous Distillation Membranes
( Elsevier Ltd , 2018 , Article)The rate of heat and mass transfer through distillation membranes is typically estimated using an over-simplified, straight-cylindrical-pore approach coupled with several empirical correction factors that are included to ... -
Molecular dynamics and combined docking studies for the identification of Zaire ebola virus inhibitors
( Taylor and Francis Ltd. , 2019 , Article)Ebola virus (EBOV) is a lethal human pathogen with a risk of global spread of its zoonotic infections, and Ebolavirus Zaire specifically has the highest fatality rate amongst other species. There is a need for continuous ... -
Molecular dynamics of CH4/CO2 on calcite for enhancing gas recovery
( John Wiley and Sons Inc , 2022 , Article)The effect of temperature and pressure on the adsorption of CO2 and CH4 gases on calcite (104) has been studied by means of classical molecular dynamics. The results show that carbon dioxide greatly improves methane ... -
Molecular dynamics simulations to decipher the structural and functional consequences of pathogenic missense mutations in the galactosylceramidase (GALC) protein causing Krabbe's disease.
( Taylor & Francis , 2020 , Article)Krabbe disease (KD), also known as globoid cell leukodystrophy disease, is an autosomal recessive lysosomal storage genetic disorder, which is caused by the deficiecncy of galactocerebrosidase (GALC) coding gene (). This ... -
Molecular dynamics, residue network analysis, and cross-correlation matrix to characterize the deleterious missense mutations in GALE causing galactosemia III.
( Springer , 2021 , Article)Epimerase-deficiency galactosemia (EDG) is caused by mutations in the UDP-galactose 4'-epimerase enzyme, encoded by gene GALE. Catalyzing the last reaction in the Leloir pathway, UDP-galactose-4-epimerase catalyzes the ... -
Molecular dynamics-based analyses of the structural instability and secondary structure of the fibrinogen gamma chain protein with the D356V mutation.
( Taylor & Francis , 2016 , Article)Mutations in the fibrinogen gamma chain (FGG) gene have been associated with various disorders, such as dysfibrinogenemia, thrombophilia, and hypofibrinogenemia. A literature survey showed that a residue exchange in ... -
Molecular epidemiology and genotype distribution of Human Papillomavirus (HPV) among Arab women in the state of Qatar
( BioMed Central Ltd. , 2014 , Article)Background: Human Papilloma Virus (HPV) infection is the major cause of cervical cancer worldwide. With limited data available on HPV prevalence in the Arab countries, this study aimed to identify the prevalence and ... -
Molecular Epidemiology and Genotype Distribution of Human Papillomavirus Among Arab Women in State of Qatar
(2014 , Master Thesis)Background: Human papillomavirus (HPV) are the most commonly known sexually transmitted agents. To date, few reports are available on distribution of most prevalent and variants types of HPV in Arab women. Therefore, the ... -
Molecular epidemiology of influenza, RSV, and other respiratory infections among children in Qatar: A six years report (2012–2017)
( Elsevier B.V. , 2020 , Article)Background: Studies on the etiology of respiratory infections among children in Qatar and surrounding countries are limited. Objectives: To describe the prevalence and seasonality of RSV, influenza, and other respiratory ... -
Molecular epidemiology of Rotavirus in children with gastroenteritis in Qatar
( OMICS , 2019 , Conference Paper)Acute gastroenteritis remains a major cause of morbidity and mortality of young children worldwide. The vast majority of diarrhea cases in developing and developed countries are attributable to the viruses and to a lesser ... -
Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region
( Elsevier , 2022 , Article)Acute gastroenteritis is the cause of considerable mortality and morbidity worldwide, particularly among children under five years in underdeveloped countries. Most acute gastroenteritis (AGE) cases are attributed to viral ... -
Molecular Evidence of Anticancer Activity of Camel Milk Combined with Camel Urine
( Austin Publishing Group , 2021 , Article)Camel Milk (CM) and Camel Urine (CU) is a traditional practice in the Middle East and other countries as an alternative treatment against cancer. We hypothesized that a combination of CM and CU (CM+CU), used at ... -
Molecular Evidence of Breast Cancer Cell Proliferation Inhibition by a Combination of Selected Qatari Medicinal Plants Crude Extracts
( MDPI , 2023 , Article): Breast cancer (BC) is the most common malignancy, and conventional medicine has failed to establish efficient treatment modalities. Conventional medicine failed due to lack of knowledge of the mechanisms that underpin ... -
MOLECULAR FEATURES OF TRIPLE NEGATIVE BREAST CANCER STEM CELLS: A GENE EXPRESSION PROFILING ANALYSIS OF MDA-MB-231 CELLS
(2021 , Master Thesis)Triple negative breast cancer (TNBC) is a chemoresistant subtype of female breast tumors. Chemoresistance is attributed to the presence of long-lived cancer stem cells (CSCs) responsible for therapy failure. This study ... -
Molecular identification and biocontrol of ochratoxigenic fungi and ochratoxin A in animal feed marketed in the state of Qatar
( Elsevier Ltd , 2023 , Article)Ochratoxin A (OTA) is a toxic fungal metabolite produced by some Aspergillus and Penicillium species. This work was designed to explore the presence of OTA and ochratoxigenic fungi in feed grains marketed in Qatar and their ... -
Molecular identification and characterization of Cryptosporidium spp. among pediatric and food-handlers subjects in Qatar
( Frontiers Media , 2017 , Article)World Health Organization (WHO) has identified Cryptosporidium spp. as globally the most common diarrhea-causing protozoan. Its transmission occurs mainly through ingestion of water or food contaminated with the feces of ...