Browsing by Author "Younes, Salma"
Now showing items 21-32 of 32
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Involvement of Essential Signaling Cascades and Analysis of Gene Networks in Diabesity
S, Udhaya Kumar; Rajan, Bithia; D, Thirumal Kumar; V, Anu Preethi; Abunada, Taghreed; Younes, Salma; Okashah, Sarah; Ethiraj, Selvarajan; C, George Priya Doss; Zayed, Hatem... more authors ... less authors ( MDPI , 2020 , Article)(1) Aims: Diabesity, defined as diabetes occurring in the context of obesity, is a serious health problem that is associated with an increased risk of premature heart attack, stroke, and death. To date, a key challenge has ... -
Management of chronic myeloid leukaemia: current treatment options, challenges, and future strategies.
Younes, Salma; Ismail, Mohamed A; Al-Jurf, Rana; Ziyada, Ayah; Nasrallah, Gheyath K; Abdulrouf, Palli Valapila; Nagy, Mohamed; Zayed, Hatem; Farrell, Thomas; Sorio, Claudio; Morsi, Hisham; Qoronfleh, M Walid; Al-Dewik, Nader I... more authors ... less authors ( taylor and francis online , 2023 , Article)Small molecule therapy is a critical component of targeted anticancer treatment, with tyrosine kinase inhibitors (TKIs) being the first compounds to treat the clonal Chronic Myelogenous Leukaemia (CML) translocation t ... -
Molecular dynamics, residue network analysis, and cross-correlation matrix to characterize the deleterious missense mutations in GALE causing galactosemia III.
Kumar, S Udhaya; Sankar, Srivarshini; Kumar, D Thirumal; Younes, Salma; Younes, Nadin; Siva, R; Doss, C George Priya; Zayed, Hatem... more authors ... less authors ( Springer , 2021 , Article)Epimerase-deficiency galactosemia (EDG) is caused by mutations in the UDP-galactose 4'-epimerase enzyme, encoded by gene GALE. Catalyzing the last reaction in the Leloir pathway, UDP-galactose-4-epimerase catalyzes the ... -
Neutralizing antibodies against SARS-CoV-2 are higher but decline faster in mRNA vaccinees compared to individuals with natural infection.
Abou-Saleh, Haissam; Abo-Halawa, Bushra Y; Younes, Salma; Younes, Nadin; Al-Sadeq, Duaa W; Shurrab, Farah M; Liu, Na; Qotba, Hamda; Al-Dewik, Nader; Ismail, Ahmed; Yassine, Hadi M; Abu-Raddad, Laith J; Nasrallah, Gheyath K... more authors ... less authors ( Oxford University Press , 2022 , Article)Waning protection against emerging SARS-CoV-2 variants by pre-existing antibodies elicited due to current vaccination or natural infection is a global concern. Whether this is due to the waning of immunity to SARS-COV-2 ... -
Prevalence, predictors, and outcomes of major congenital anomalies: A population-based register study
Al-Dewik, Nader; Samara, Muthanna; Younes, Salma; Al-jurf, Rana; Nasrallah, Gheyath; Al-Obaidly, Sawsan; Salama, Husam; Olukade, Tawa; Hammuda, Sara; Marlow, Neil; Ismail, Mohamed; Abu Nada, Taghreed; Qoronfleh, M. Walid; Thomas, Binny; Abdoh, Ghassan; Abdulrouf, Palli Valapila; Farrell, Thomas; Al Qubaisi, Mai; Al Rifai, Hilal... more authors ... less authors ( Nature Research , 2023 , Article)Congenital anomalies (CAs) are a leading cause of morbidity and mortality in early life. We aimed to assess the incidence, risk factors, and outcomes of major CAs in the State of Qatar. A population-based retrospective ... -
A review of novel coronavirus disease (COVID-19): based on genomic structure, phylogeny, current shreds of evidence, candidate vaccines, and drug repurposing
Kumar, S. Udhaya; Priya, N. Madhana; Nithya, S. R.; Kannan, Priyanka; Jain, Nikita; Kumar, D. Thirumal; Magesh, R.; Younes, Salma; Zayed, Hatem; Doss, C. George Priya... more authors ... less authors ( Springer Verlag , 2021 , Article Review)Coronavirus disease (COVID-19) pandemic is instigated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of March 13, 2021, more than 118.9 million cases were infected with COVID-19 worldwide. SARS-CoV-2 ... -
“Safe” Chitosan Zinc Oxide Nanocomposite Has Minimal Organ-Specific Toxicity on Early Stages of Zebrafish Development
Younes, Nadin; Pintus, Gianfranco; Al-Asmakh, Maha; Rasool, Kashif; Younes, Salma; Calzolari, Simone; Mahmoud, Khaled; Nasrallah, Gheyath... more authors ... less authors ( American Chemical Society , 2019 , Article)Marine biofouling is considered one of the most challenging issues affecting maritime industries worldwide. In this regard, traditional biocides, being used to combat biofouling, have high toxicity toward the aquatic system. ... -
Seroprevalence of SARS-CoV2 in Qatar: a longitudinal epidemiological study
Shurrab, Farah; Al-Jighefee, Hadeel; Younes, Salma; Al-Sadeq, Duaa; Althani, Asmaa; Yassine, Hadi; Syed, Mohamed; AlNuami, Ahmed; Qotba, Hamda; Nasrallah, Gheyath... more authors ... less authors ( Qatar University Press , 2020 , Poster)In Qatar, the first COVID-19 cases were reported on the 29th of February 2020, and the numbers increased dramatically within few months. Primary Health Care Corporation in collaboration with Qatar University's Biomedical ... -
Severe acute respiratory syndrome coronavirus-2 natural animal reservoirs and experimental models: systematic review.
Younes, Salma; Younes, Nadin; Shurrab, Farah; Nasrallah, Gheyath K ( John Wiley and Sons , 2020 , Article Review)The current severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak has been rapidly spreading worldwide, causing serious global concern. The role that animal hosts play in disease transmission is still ... -
The spectrum of beta-thalassemia mutations in the 22 Arab countries: a systematic review
Khan, Aisha Moeen; Al-Sulaiti, Asma Mohammed; Younes, Salma; Yassin, Mohamed; Zayed, Hatem ( Expert Reviews (formerly Future Drugs) / Taylor and Francis , 2020 , Article)To investigate the mutational spectrum in gene in Arab patients with Beta-Thalassemia (β-thal). Authors searched five databases (PubMed, Science Direct, Scopus, Web of Science, and Google Scholar) from the time of inception ... -
Validation of Selected Commercial Serological Assays for Diagnosis of COVID-19
Younes, Salma; Al-Jighefee, Hadeel; Shurrab, Farah; Al-Sadeq, Duaa; Yassine, Hadi; Althani, Asmaa; Marei, Reham; Alhussain, Hashim; Nasrallah, Gheyath... more authors ... less authors ( Qatar University Press , 2020 , Poster)As researchers around the globe rush to put the available antibody tests to use, concerns have been raised about their precision. This study aimed to evaluate and compare the performance of selected commercial & automated ... -
Whole-exome sequencing analysis of NSCLC reveals the pathogenic missense variants from cancer-associated genes
Kumar S, Udhaya; Balasundaram, Ambritha; Cathryn R, Hephzibah; Varghese, Rinku Polachirakkal; R, Siva; R, Gnanasambandan; Younes, Salma; Zayed, Hatem; Doss C, George Priya... more authors ... less authors ( Elsevier , 2022 , Article)Background: Non-small-cell lung cancer (NSCLC) is the most common type of lung cancer. NSCLC accounts for 84% of all lung cancer cases. In recent years, advances in pathway understanding, methods for discovering novel ...