Identification of a 48 kDa form of unconventional myosin 1c in blood serum of patients with autoimmune diseases.
المؤلف | Myronovkij, Severyn |
المؤلف | Negrych, Nazar |
المؤلف | Nehrych, Tetyana |
المؤلف | Redowicz, Maria J |
المؤلف | Souchelnytskyi, Serhiy |
المؤلف | Stoika, Rostyslav |
المؤلف | Kit, Yuriy |
تاريخ الإتاحة | 2019-02-13T08:43:24Z |
تاريخ النشر | 2016-03-01 |
اسم المنشور | Biochemistry and Biophysics Reports |
المعرّف | http://dx.doi.org/10.1016/j.bbrep.2015.12.001 |
الاقتباس | Myronovkij, S., Negrych, N., Nehrych, T., Redowicz, M. J., Souchelnytskyi, S., Stoika, R., & Kit, Y. (2015). Identification of a 48 kDa form of unconventional myosin 1c in blood serum of patients with autoimmune diseases. Biochemistry and biophysics reports, 5, 175-179. doi:10.1016/j.bbrep.2015.12.001 |
الرقم المعياري الدولي للكتاب | 2405-5808 |
الملخص | We searched for protein markers present in blood serum of multiple sclerosis (MS), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients in comparison to healthy human individuals. We used precipitation/extraction methods and MALDI TOF/TOF mass spectrometry, and identified a protein with Mr ~46 kDa as a fragment of human unconventional myosin IC isoform b (Myo1C). Western blotting with specific anti-human Myo1C antibodies confirmed the identity. Screening of blood serum samples from different autoimmune patients for the presence of Myo1c revealed its high level in MS and RA patients, relatively low level in SLE patients, and undetected in healthy donors. These data are suggesting that the level of p46 Myo1C in blood serum is a potential marker for testing of autoimmune diseases. |
راعي المشروع | NPRP9-453-3-089, QU internal grants |
اللغة | en |
الناشر | Elsevier |
الموضوع | Autoimmune diseases Human blood serum MS, multiple sclerosis NHD, normal healthy donors PA, rheumatoid arthritis SLE, systemic lupus erythematosis TCA-extracted proteins |
النوع | Article |
الصفحات | 175-179 |
رقم المجلد | 5 |
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