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AuthorMyronovkij, Severyn
AuthorNegrych, Nazar
AuthorNehrych, Tetyana
AuthorRedowicz, Maria J
AuthorSouchelnytskyi, Serhiy
AuthorStoika, Rostyslav
AuthorKit, Yuriy
Available date2019-02-13T08:43:24Z
Publication Date2016-03-01
Publication NameBiochemistry and Biophysics Reports
CitationMyronovkij, S., Negrych, N., Nehrych, T., Redowicz, M. J., Souchelnytskyi, S., Stoika, R., & Kit, Y. (2015). Identification of a 48 kDa form of unconventional myosin 1c in blood serum of patients with autoimmune diseases. Biochemistry and biophysics reports, 5, 175-179. doi:10.1016/j.bbrep.2015.12.001
AbstractWe searched for protein markers present in blood serum of multiple sclerosis (MS), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients in comparison to healthy human individuals. We used precipitation/extraction methods and MALDI TOF/TOF mass spectrometry, and identified a protein with Mr ~46 kDa as a fragment of human unconventional myosin IC isoform b (Myo1C). Western blotting with specific anti-human Myo1C antibodies confirmed the identity. Screening of blood serum samples from different autoimmune patients for the presence of Myo1c revealed its high level in MS and RA patients, relatively low level in SLE patients, and undetected in healthy donors. These data are suggesting that the level of p46 Myo1C in blood serum is a potential marker for testing of autoimmune diseases.
SponsorNPRP9-453-3-089, QU internal grants
SubjectAutoimmune diseases
SubjectHuman blood serum
SubjectMS, multiple sclerosis
SubjectNHD, normal healthy donors
SubjectPA, rheumatoid arthritis
SubjectSLE, systemic lupus erythematosis
SubjectTCA-extracted proteins
TitleIdentification of a 48 kDa form of unconventional myosin 1c in blood serum of patients with autoimmune diseases.
Volume Number5

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