Identification of SER-PRO-CYS Peptide in Blood Serum of Multiple Sclerosis Patients
المؤلف | Myronovkij, Severyn |
المؤلف | Negrych, Nazar |
المؤلف | Nehrych, Tetyana |
المؤلف | Tkachenko, Volodymyr |
المؤلف | Souchelnytskyi, Serhiy |
المؤلف | Stoika, Rostyslav |
المؤلف | Kit, Yuriy |
تاريخ الإتاحة | 2019-02-13T09:55:47Z |
تاريخ النشر | 2016-09-15 |
اسم المنشور | Protein and Peptide Letters |
الاقتباس | Myronovkij, Severyn. et al. "Identification of SER-PRO-CYS Peptide in Blood Serum of Multiple Sclerosis Patients", Protein and Peptide Letters, Volume 23, Number 9, September 2016, pp. 808-811(4) |
الرقم المعياري الدولي للكتاب | 0929-8665 |
الملخص | Monitoring of multiple sclerosis (MS) requires additional molecular markers. Recently, we used original TCA-precipitation/extraction approach in combination with MALDI TOF/TOF mass-spectrometry and identified earlier unknown 48 kDa form of the unconventional myosin IC isoform b (Myo1C) in blood serum of the MS patients. Further examination of TCA-extracted fraction of blood serum of these patients by means of thin-layer chromatography and HPLC gel-filtration allowed detecting 300-500 Da peptides. MALDI TOF/TOF massspectrometry of these peptides showed that they contain Ser-Pro-Cys amino acid sequence. We discussed potential mechanisms of a release of these peptides that were earlier unknown in blood serum of the MS patients. |
راعي المشروع | NPRP9-453-3-089, QU internal grants |
اللغة | en |
الناشر | Bentham Science Publishers |
الموضوع | blood serum Multiple sclerosis peptides Amino Acid Sequence Adult Biomarkers/blood Cysteine/metabolism Female Male Humans Middle Aged Multiple Sclerosis/metabolism Peptides/blood Peptides/chemistry Peptides/isolation & purification Proline/metabolism Serine/metabolism Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Tandem Mass Spectrometry Young Adult |
النوع | Article |
رقم العدد | 9 |
رقم المجلد | 23 |
ESSN | 1875-5305 |
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