| Author | Myronovkij, Severyn |
| Author | Negrych, Nazar |
| Author | Nehrych, Tetyana |
| Author | Tkachenko, Volodymyr |
| Author | Souchelnytskyi, Serhiy |
| Author | Stoika, Rostyslav |
| Author | Kit, Yuriy |
| Available date | 2019-02-13T09:55:47Z |
| Publication Date | 2016-09-15 |
| Publication Name | Protein and Peptide Letters | en_US |
| Citation | Myronovkij, Severyn. et al. "Identification of SER-PRO-CYS Peptide in Blood Serum of Multiple Sclerosis Patients", Protein and Peptide Letters, Volume 23, Number 9, September 2016, pp. 808-811(4) |
| ISSN | 0929-8665 |
| URI | http://hdl.handle.net/10576/11317 |
| Abstract | Monitoring of multiple sclerosis (MS) requires additional molecular markers. Recently, we used original TCA-precipitation/extraction approach in combination with MALDI TOF/TOF mass-spectrometry and identified earlier unknown 48 kDa form of the unconventional myosin IC isoform b (Myo1C) in blood serum of the MS patients. Further examination of TCA-extracted fraction of blood serum of these patients by means of thin-layer chromatography and HPLC gel-filtration allowed detecting 300-500 Da peptides. MALDI TOF/TOF massspectrometry of these peptides showed that they contain Ser-Pro-Cys amino acid sequence. We discussed potential mechanisms of a release of these peptides that were earlier unknown in blood serum of the MS patients. |
| Sponsor | NPRP9-453-3-089, QU internal grants |
| Language | en |
| Publisher | Bentham Science Publishers |
| Subject | blood serum |
| Subject | Multiple sclerosis |
| Subject | peptides |
| Medical Subject Headings | Adult |
| Medical Subject Headings | Amino Acid Sequence |
| Medical Subject Headings | Biomarkers/blood |
| Medical Subject Headings | Cysteine/metabolism |
| Medical Subject Headings | Female |
| Medical Subject Headings | Humans |
| Medical Subject Headings | Male |
| Medical Subject Headings | Middle Aged |
| Medical Subject Headings | Multiple Sclerosis/metabolism |
| Medical Subject Headings | Peptides/blood |
| Medical Subject Headings | Peptides/chemistry |
| Medical Subject Headings | Peptides/isolation & purification |
| Medical Subject Headings | Proline/metabolism |
| Medical Subject Headings | Serine/metabolism |
| Medical Subject Headings | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization |
| Medical Subject Headings | Tandem Mass Spectrometry |
| Medical Subject Headings | Young Adult |
| Title | Identification of SER-PRO-CYS Peptide in Blood Serum of Multiple Sclerosis Patients |
| Type | Article |
| Issue Number | 9 |
| Volume Number | 23 |
|
dc.identifier.essn
| 1875-5305 |
