Intersection between genes controlling vascularization and angiogenesis in renal cell carcinomas
المؤلف | Souchelnytskyi, S |
تاريخ الإتاحة | 2019-02-14T08:02:49Z |
تاريخ النشر | 2018-06-01 |
اسم المنشور | British Journal of Cancer - Experimental Oncology |
الاقتباس | Souchelnytskyi S. Intersection between genes controlling vascularization and angiogenesis in renal cell carcinomas. British Journal of Cancer - Experimental Oncology. Vol 40, Issue (2), P.p. 140-143 |
الرقم المعياري الدولي للكتاب | 0007-0920 |
الملخص | To show that application of the systemic analysis may significantly improve comparison of different datasets. Different genes and proteins may converge on the same functional outputs. A comparison of 2 datasets by only identification names of affected molecules may miss that, leading to a conclusion that there is nothing in common for these datasets. Systemic analysis may overcome this limitation, by focusing on functions represented by the identification names. Datasets were retrieved from open sources. Systemic analysis of vascularization features and angiogenesis signature was performed by using Cytoscape and its plugs-in. In contrary to the initial statement of the lack of overlap between the vascularization features and the angiogenesis genes-signature in renal carcinomas, we observed an intersection on the functional level. Analysis of the networks built with identification names of vascularization and angiogenesis datasets showed an intersection, which included potent regulators of vessel formation and growth. Analysis of networks may expose functional links, which may be missed by a direct identification names comparison. |
راعي المشروع | NPRP9-453-3-089 |
اللغة | en |
الناشر | Springer Nature |
الموضوع | cancer angiogenesis vascularization systemic analysis Carcinoma, Renal Cell/genetics Carcinoma, Renal Cell/pathology Computational Biology/methods Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Kidney Neoplasms/pathology Kidney Neoplasms/pathology Molecular Sequence Annotation Neovascularization, Pathologic/genetics Transcriptome |
النوع | Article |
الصفحات | 140-143 |
رقم العدد | 2 |
رقم المجلد | 40 |
ESSN | 1532-1827 |
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