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AuthorAl-Qahdi, Shaikha S
AuthorAlzohari, Nada
AuthorAlsaid, Abrar Y
AuthorAshour, Anas A
AuthorAboulkassim, Tahar
AuthorVranic, Semir
AuthorAl Moustafa, Ala-Eddin
AuthorKhalil, Ashraf A
Available date2019-03-28T08:18:09Z
Publication Date2019-02-01
Publication NameBosnian Journal of Basic Medical Scienceen_US
Identifierhttp://dx.doi.org/10.17305/bjbms.2018.4052
CitationAl-Qahdi SS, Alzohari N, Alsaid AY, Ashour AA, Aboulkassim T, Vranic S, Al Moustafa A-E, Khalil AA. Teucrium Polium Plant Extract Provokes Substantial Cytotoxicity at the Early Stage of Embryonic Development. Bosn J of Basic Med Sci [Internet]. 2019Feb.12 [cited 2019Mar.28];19(1):67-1. Available from: http://www.bjbms.org/ojs/index.php/bjbms/article/view/4052
ISSN1512-8601
URIhttp://hdl.handle.net/10576/11457
AbstractThe aim of this study is to explore the outcome of Teucrium polium (TP) medicinal plant consumption on the early stage of fetal development. We used the chicken embryo at 3 days of incubation as a model to evaluate the effect of TP plant extract during embryogenesis. In addition, quantitative polymerase chain reaction (qPCR) was applied to explore the expression of six genes related to cell proliferation, apoptosis, sur-vival, angiogenesis, and migration. Our data revealed that TP exposure inhibits angiogenesis of the chicken embryo and its chorioallantoic membrane. In addition, we found that TP extract significantly harms the normal development of the embryos since around 95% of TP-exposed embryos died after 1-3 days of treatment. Macroscopic examination did not show any anomalies in these embryos. However, qPCR analysis of activation transcription factor-3, B-cell lymphoma-2, caspase 8, inhibin subunit beta A, vascular endothelial growth factor-C, and Cadherin-6 type-2 genes revealed that these genes are considerably deregulated in heart and brain tissues from TP-exposed embryos in comparison with their matched tissues from unexposed ones. Our study implies that TP plant can have very toxic effects on the early stage of the embryo. Therefore, it is important to alert expectant women to avoid the use of this medicinal plant during pregnancy.
Languageen
PublisherAssociation of Basic Medical Sciences of Federation of Bosnia and Herzegovina
SubjectEmbryonic development
Subjectmedicinal plant
Subjecttoxic effects
SubjectTeucrium polium
Subjectembryo
Subjectangiogenesis
Subjecttoxicity
Subjectgene deregulations
TitleTeucrium Polium Plant Extract Provokes Substantial Cytotoxicity at the Early Stage of Embryonic Development.
TypeArticle
Issue Number1
Volume Number19
dc.identifier.essn 1840-4812


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