Show simple item record

AuthorCyprian, Farhan S
AuthorAl-Farsi, Halema F
AuthorVranic, Semir
AuthorAkhtar, Saghir
AuthorAl Moustafa, Ala-Eddin
Available date2019-04-03T11:46:03Z
Publication Date2018-05-01
Publication NameFrontiers in Oncology
Identifierhttp://dx.doi.org/10.3389/fonc.2018.00111
CitationCyprian FS, Al-Farsi HF, Vranic S, Akhtar S and Al Moustafa A-E (2018) Epstein–Barr Virus and Human Papillomaviruses Interactions and Their Roles in the Initiation of Epithelial–Mesenchymal Transition and Cancer Progression. Front. Oncol. 8:111. doi: 10.3389/fonc.2018.00111
IdentifierArticle # 111
URIhttp://hdl.handle.net/10576/11468
AbstractOncoviruses are implicated in around 20% of all human cancers including both solid and non-solid malignancies. Epstein-Barr virus (EBV) and human papillomaviruses (HPVs) are the most common oncoviruses worldwide. Currently, it is well established that onco-proteins of EBV (LMP1, LMP2A, and EBNA1) and high-risk HPVs (E5 and E6/E7) play an important role in the initiation and/or progression of several human carcinomas, including cervical, oral, and breast. More significantly, it has been recently pointed out that viral onco-proteins of EBV and high-risk HPVs can be co-present and consequently cooperate to initiate and/or amplify epithelial-mesenchymal transition (EMT), which is the hallmark of cancer progression and metastasis. This could occur by β-catenin, JAK/STAT/SRC, PI3k/Akt/mTOR, and/or RAS/MEK/ERK signaling pathways, which onco-proteins of EBV and HPVs share. This review presents the most recent advances related to EBV and high-risk HPVs onco-proteins interactions and their roles in the progression of human carcinomas especially oral and breast the initiation of EMT.
SponsorThis review presents the most recent advances related to EBV and high-risk HPVs onco-proteins interactions and their roles in the progression of human carcinomas especially oral and breast via the initiation of EMT.
Languageen
PublisherFrontiers Media
SubjectEpstein–Barr virus
cancer progression
epithelial–mesenchymal transition
high-risk human papillomaviruses
onco-proteins
TitleEpstein-Barr Virus and Human Papillomaviruses Interactions and Their Roles in the Initiation of Epithelial-Mesenchymal Transition and Cancer Progression.
TypeArticle Review
Volume Number8
ESSN2234-943X
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record