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AuthorWillenbacher, Wolfgang
AuthorSeeber, Andreas
AuthorSteiner, Normann
AuthorWillenbacher, Ella
AuthorGatalica, Zoran
AuthorSwensen, Jeff
AuthorKimbrough, Jeffery
AuthorVranic, Semir
Available date2019-04-04T09:02:41Z
Publication Date2018-07-01
Publication NameInternational Journal of Molecular Sciencesen_US
Identifierhttp://dx.doi.org/10.3390/ijms19072087
CitationWillenbacher, W.; Seeber, A.; Steiner, N.; Willenbacher, E.; Gatalica, Z.; Swensen, J.; Kimbrough, J.; Vranic, S. Towards Molecular Profiling in Multiple Myeloma: A Literature Review and Early Indications of Its Efficacy for Informing Treatment Strategies. Int. J. Mol. Sci. 2018, 19, 2087
ISSN1661-6596
URIhttp://hdl.handle.net/10576/11474
AbstractMultiple myeloma (MM), the second most common hematologic malignancy, is characterized by the clonal expansion of plasma cells. Despite dramatic improvements in patients' survival over the past decade due to advances in therapy exploiting novel molecular targets (immunomodulatory drugs, proteasome inhibitors and monoclonal antibodies), the treatment of relapsed and refractory disease remains challenging. Recent studies confirmed complex, dynamic, and heterogeneous genomic alterations without unifying gene mutations in MM patients. In the current review, we survey recent therapeutic strategies, as well as molecular profiling data on MM, with emphasis on relapsed and refractory cases. A critical appraisal of novel findings and of their potential therapeutic implications will be discussed in detail, along with the author's own experiences/views.
Languageen
PublisherMDPI
Subjectmolecular profiling
Subjectmultiple myeloma
Subjectplasma cell dyscrasias
Subjecttreatment
TitleTowards Molecular Profiling in Multiple Myeloma: A Literature Review and Early Indications of Its Efficacy for Informing Treatment Strategies.
TypeArticle
Volume Number19
dc.identifier.essn 1422-0067


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