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المؤلفZaheer, Uzma
المؤلفFaheem, Muhammed
المؤلفQadri, Ishtiaq
المؤلفBegum, Nargis
المؤلفYassine, Hadi M
المؤلفAl Thani, Asmaa A
المؤلفMathew, Shilu
تاريخ الإتاحة2019-04-16T10:16:21Z
تاريخ النشر2019-03-01
اسم المنشورCurrent Pharmaceutical Design
المعرّفhttp://dx.doi.org/10.2174/1386207322666190325122821
الاقتباسUzma Zaheer et. al . Expression profile of MicroRNA: An Emerging Hallmark of Cancer. Current Pharmaceutical Design. Vol. 25 , P.p. 1-12
الرقم المعياري الدولي للكتاب1381-6128
معرّف المصادر الموحدhttp://hdl.handle.net/10576/11484
الملخصMicroRNA (miRNAs), a class of small, endogenous non-coding RNA molecules of about 21-24 nucleotides in length, have unraveled a new modulatory network of RNAs that form an additional level of post-transcriptional gene regulation by targeting messenger RNAs (mRNAs). These miRNAs possess the ability to regulate gene expression by modulating the stability of mRNAs, controlling their translation rates, and consequently regulating protein synthesis. Substantial experimental evidence established the involvement of miRNAs in most biological processes like growth, differentiation, development, and metabolism in mammals including humans. Aberrant expression of miRNAs have been implicated in several pathologies, including cancer. Association of miRNAs with tumor growth, development, and metastasis depict its potential as effective diagnostic and prognostic biomarkers. Furthermore, exploitation of the role of different miRNAs as oncogenes or tumor suppressors have aided in designing several miRNA-based therapeutic approaches for treating cancer patients whose clinical trials are underway. In this review, we aim to summarize the biogenesis of miRNAs and the dysregulations in these pathways that result in various pathologies and in some cases, resistance to drug treatment. We provide a detailed review of the miRNA expression signatures in different cancers along with their diagnostic and prognostic utility. Furthermore, we elaborate the potential employment of miRNAs to enhance cancer cell apoptosis, regress tumor progression and even overcome miRNA induced drug resistance.
اللغةen
الناشرBentham Science Publishers
الموضوعCancer
Diagnosis
Prognosis
Therapy
TherapymiRNAs
miRNAs
العنوانExpression profile of MicroRNA: An Emerging Hallmark of Cancer.
النوعArticle Review
الصفحات1-12
رقم المجلد25
ESSN1873-4286
dc.accessType Abstract Only


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