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AuthorHussein, Essraa
AuthorZagho, Moustafa
AuthorRizeq, Balsam
AuthorYounes, Nadin
AuthorPintus, Gianfranco
AuthorMahmoud, Khaled
AuthorNasrallah, Gheyath
AuthorElzatahry, Ahmed
Available date2019-07-01T10:21:32Z
Publication Date2019-05-14
Publication NameInternational journal of nanomedicineen_US
Identifierhttp://dx.doi.org/10.2147/IJN.S202208
CitationHussein, E. A., Zagho, M. M., Rizeq, B. R., Younes, N. N., Pintus, G., Mahmoud, K. A., ... & Elzatahry, A. A. (2019). Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene. International Journal of Nanomedicine, 14, 4529-4539.
ISSN1176-9114
URIhttp://hdl.handle.net/10576/11640
AbstractPurpose: Here, we fabricated two plasmonic 2D Ti3C2Tx-based nanocomposites (Au/MXene and Au/Fe3O4/MXene) with similarly high anti-cancer photothermal therapy (PTT) capabilities, but with less in vivo toxicity than a pure MXene. Methods: Au/MXene was synthesized by in situ reduction of tetrachloroauric acid using NaBH4 on Ti3C2Tx flakes. For targeted PTT, magnetic Au/Fe3O4/MXene was synthesized via a reaction between freshly prepared magnetite Fe3O4 NPs and MXene solution, followed by in situ integration of gold nanoparticles (AuNPs). Results: Morphological characterization by XRD, SEM, and TEM revealed the successful synthesis of Au/MXene and Au/Fe3O4/MXene. Both new composites exhibited a significant in vitro dose-dependent PTT effect against human breast cancer cells MCF7. Interestingly, in vivo acute toxicity assays using zebrafish embryos indicated that Au/MXene and Au/Fe3O4/MXene had less embryonic mortality (LC50 ≫ 1000 μg/mL) than pure MXene (LC50=257.46 μg/mL). Conclusion: Our new Au/MXene and Au/Fe3O4/MXene nanocomposites could be safer and more suitable than the pure MXene for biomedical applications, especially when targeted PTT is warranted.
SponsorThis work was supported by Qatar University under High Impact-Fund Program Grant QUHI-CAS-19/20-1. The authors are thankful to S. Suslov, A. Samara at the Core lab of QEERI/HBKU, Doha, Qatar, for TEM, DLS, and VSM analysis. The publication of this article was funded by the Qatar National Library. The authors have neither other relevant affiliations nor financial involvement with any entity or organization with a financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
Languageen
PublisherDOVE Medical Press
SubjectMXene
Subjectgold
Subjectacute toxicity
Subjectphotothermal therapy
Subjectmagnetite
SubjectMCF7
TitlePlasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene
TypeArticle
Pagination4529-4539
Volume Number14
ESSN1178-2013


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