عرض بسيط للتسجيلة

المؤلفHussein, Essraa
المؤلفZagho, Moustafa
المؤلفRizeq, Balsam
المؤلفYounes, Nadin
المؤلفPintus, Gianfranco
المؤلفMahmoud, Khaled
المؤلفNasrallah, Gheyath
المؤلفElzatahry, Ahmed
تاريخ الإتاحة2019-07-01T10:21:32Z
تاريخ النشر2019-05-14
اسم المنشورInternational journal of nanomedicineen_US
المعرّفhttp://dx.doi.org/10.2147/IJN.S202208
الاقتباسHussein, E. A., Zagho, M. M., Rizeq, B. R., Younes, N. N., Pintus, G., Mahmoud, K. A., ... & Elzatahry, A. A. (2019). Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene. International Journal of Nanomedicine, 14, 4529-4539.
الرقم المعياري الدولي للكتاب1176-9114
معرّف المصادر الموحدhttp://hdl.handle.net/10576/11640
الملخصPurpose: Here, we fabricated two plasmonic 2D Ti3C2Tx-based nanocomposites (Au/MXene and Au/Fe3O4/MXene) with similarly high anti-cancer photothermal therapy (PTT) capabilities, but with less in vivo toxicity than a pure MXene. Methods: Au/MXene was synthesized by in situ reduction of tetrachloroauric acid using NaBH4 on Ti3C2Tx flakes. For targeted PTT, magnetic Au/Fe3O4/MXene was synthesized via a reaction between freshly prepared magnetite Fe3O4 NPs and MXene solution, followed by in situ integration of gold nanoparticles (AuNPs). Results: Morphological characterization by XRD, SEM, and TEM revealed the successful synthesis of Au/MXene and Au/Fe3O4/MXene. Both new composites exhibited a significant in vitro dose-dependent PTT effect against human breast cancer cells MCF7. Interestingly, in vivo acute toxicity assays using zebrafish embryos indicated that Au/MXene and Au/Fe3O4/MXene had less embryonic mortality (LC50 ≫ 1000 μg/mL) than pure MXene (LC50=257.46 μg/mL). Conclusion: Our new Au/MXene and Au/Fe3O4/MXene nanocomposites could be safer and more suitable than the pure MXene for biomedical applications, especially when targeted PTT is warranted.
راعي المشروعThis work was supported by Qatar University under High Impact-Fund Program Grant QUHI-CAS-19/20-1. The authors are thankful to S. Suslov, A. Samara at the Core lab of QEERI/HBKU, Doha, Qatar, for TEM, DLS, and VSM analysis. The publication of this article was funded by the Qatar National Library. The authors have neither other relevant affiliations nor financial involvement with any entity or organization with a financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
اللغةen
الناشرDOVE Medical Press
الموضوعMXene
الموضوعgold
الموضوعacute toxicity
الموضوعphotothermal therapy
الموضوعmagnetite
الموضوعMCF7
العنوانPlasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene
النوعArticle
الصفحات4529-4539
رقم المجلد14
ESSN1178-2013


الملفات في هذه التسجيلة

الملفاتالحجمالصيغةالعرض

لا توجد ملفات لها صلة بهذه التسجيلة.

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة