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AuthorGendron, Louis
AuthorNagi, Karim
AuthorZeghal, Manel
AuthorGiguère, Patrick M
AuthorPineyro, Graciela
Available date2019-09-15T05:39:35Z
Publication Date2019
Publication NameVitamins and Hormones
Identifierhttp://dx.doi.org/10.1016/bs.vh.2019.06.001
CitationGendron L, Nagi K, Zeghal M, Giguère PM, Pineyro G. Molecular aspects of delta opioid receptors. Vitam Horm. 2019;111:49-90. doi: 10.1016/bs.vh.2019.06.001.
ISBN978-0-12-818858-3
ISSN0083-6729
URIhttp://hdl.handle.net/10576/11830
AbstractThe delta opioid receptor (DOP) belongs to the Class A, rhodopsin-like family of G protein-coupled receptors. Although this receptor has a high level of similarity with the other opioid receptors, it displays unique aspects and functions. Indeed, as opposed to most membrane receptors, DOP is poorly addressed to the plasma membrane. In this chapter, we first review the molecular and cellular mechanisms regulating the expression and the cellular trafficking/sorting of DOP. We then summarize the structural insights of this receptor through the analysis of the existing crystal structures, with a particular focus on the role of the sodium binding site. Finally, we review the current signaling mechanisms mediating receptor function and desensitization.
Languageen
PublisherElsevier
SubjectDelta opioid receptor
Desensitization
Expression
Regulation
Signaling
Sorting
Structure
Trafficking
TitleMolecular aspects of delta opioid receptors.
TypeArticle
Pagination49-90
Volume Number111
dc.accessType Abstract Only


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