| Author | Bhuiyan T.A. |
| Author | Graff C. |
| Author | Kanters J.K. |
| Author | Melgaard J. |
| Author | Toft E. |
| Author | K??b S. |
| Author | Struijk J.J. |
| Available date | 2019-09-30T07:47:43Z |
| Publication Date | 2018 |
| Publication Name | Clinical Pharmacology and Therapeutics |
| Resource | Scopus |
| ISSN | 0009-9236 |
| URI | http://dx.doi.org/10.1002/cpt.886 |
| URI | http://hdl.handle.net/10576/11983 |
| Abstract | The hypothesis of the study is that Torsades de pointes (TdP) history can be better identified using T-wave morphology compared to Fridericia-corrected QT interval (QTcF) at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (–TdP). The QTcF and T-wave morphology combination score (MCS) were calculated. At baseline, there was no significant difference in QTcF between the groups (+TdP: QTcF = 446 ± 9 ms; –TdP: QTcF = 431 ± 9 ms, P = 0.27). In contrast, MCS was significantly different between the groups at baseline (+TdP: MCS = 1.07 ± 0.095; –TdP: MCS = 0.74 ± 0.07, P = 0.012). Both QTcF and MCS could be used to discriminate between +TdP and –TdP after sotalol but only MCS reached statistical significance at baseline. Combining QTcF with MCS provided a significantly larger difference between groups than QTcF alone. © 2017 American Society for Clinical Pharmacology and Therapeutics |
| Sponsor | This work was supported by the Danish Council for Strategic Research (HEARTSAFE Grant Number: 10-092799).
22. Drew, B.J. et al. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. Circulation. 121, 1047� 1060 (2010). |
| Language | en |
| Publisher | Nature Publishing Group |
| Title | A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities |
| Type | Article |
| Pagination | 1100-1106 |
| Issue Number | 6 |
| Volume Number | 103 |
