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AuthorAl-Antary, Noor
AuthorFarghaly, Hanan
AuthorAboulkassim, Tahar
AuthorYasmeen, Amber
AuthorAkil, Nizar
AuthorAl Moustafa, Ala-Eddin
Available date2019-10-16T07:03:06Z
Publication Date2017-07-03
Publication NameHuman Vaccines and Immunotherapeutics
Identifierhttp://dx.doi.org/10.1080/21645515.2017.1302046
CitationAl-Antary, Noor & Farghaly, Hanan & Aboulkassim, Tahar & Yasmeen, Amber & Akil, Nizar & Al Moustafa, Ala-Eddin. (2017). Epstein–Barr virus and its association with Fascin expression in colorectal cancers in the Syrian population: A tissue microarray study. Human vaccines & immunotherapeutics. 13. 10.1080/21645515.2017.1302046.
ISSN2164-5515
URIhttp://hdl.handle.net/10576/12128
AbstractColorectal cancer (CRC) is the third most common malignancy in both men and women worldwide. Colorectal carcinogenesis is a complex, multistep process involving environmental and lifestyle features as well as sequential genetic changes in addition to bacterial and viral infections. Viral infection has a proven role in the incidence of approximately 20% of human cancers including gastric malignancies. Accordingly, Epstein-Barr virus (EBV) has been recently shown to be present in human gastric cancers, which could play an important role in the initiation and progression of these cancers. Therefore, this work explores the prevalence of EBV in 102 CRC tissues from the Syrian population using polymerase chain reaction (PCR) and tissue microarray (TMA) analysis. We found that EBV is present in 37 (36.27%) of CRC samples. Additionally, the expression of LMP1 onco-protein of EBV was found to be correlated with Fascin expression/overexpression in the majority of CRC tissue samples, which are intermediate/high grade invasive carcinomas. Our data indicate that EBV is present in CRC and its presence is associated with more aggressive cancer phenotype. Consequently, future investigations are needed to expose the role of EBV in CRC initiation and progression.
SponsorThis work is supported by the College of Medicine and Qatar University.
Languageen
PublisherTaylor & Francis
SubjectCancer phenotype
EBV
Fascin
Syrian population
colorectal cancers
TitleEpstein-Barr virus and its association with Fascin expression in colorectal cancers in the Syrian population: A tissue microarray study.
TypeArticle
Pagination1573-1578
Issue Number7
Volume Number13
ESSN2164-554X
dc.accessType Abstract Only


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