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AuthorAl Moustafa, Ala-Eddin
AuthorAl-Antary, Noor T M
Available date2019-10-16T07:16:42Z
Publication Date2016-04-01
Publication NameCanceren_US
Identifierhttp://dx.doi.org/10.1002/cncr.29905
CitationAl Moustafa, A. and Al‐Antary, N. T. (2016), Specific gene patterns and molecular pathways related to human carcinogenesis in different populations among various geographic locations. Cancer, 122: 1134-1135. doi:10.1002/cncr.29905
ISSN0008-543X
URIhttp://hdl.handle.net/10576/12129
AbstractWe read with great interest the article by Beg et al,1 which was recently published in Cancer. Colorectal cancers (CRCs) are the most commonly diagnosed malignancies, accounting for approximately 1.36 million new cases worldwide every year.2 Colorectal carcinogenesis is a complex, multistep process involving environmental and lifestyle factors in addition to sequential genetic changes and possibly viral components. Currently, the majority of deaths from CRC occur in developing countries including the Middle East, in which the incidence of CRC is rising. CRCs are characterized by a marked propensity toward invasion and spread to local lymph nodes. The overall 5‐year survival rate for patients diagnosed with CRC is approximately 60% and to our knowledge this rate has not significantly improved over the past 2 decades.3 Therefore, new preventive and therapeutic strategies to circumvent various stages of carcinogenesis in CRC are becoming a major investigative focus. To achieve this goal, a comprehensive understanding of the genetic interactions associated with early events in colorectal carcinogenesis is an essential first step.
SponsorCollege of Medicine at Qatar University.
Languageen
PublisherWiley
SubjectSpecific gene patterns
Subjectdifferent populations
TitleSpecific gene patterns and molecular pathways related to human carcinogenesis in different populations among various geographic locations.
TypeOther
Pagination1134-1135
Issue Number7
Volume Number122
dc.identifier.essn 1097-0142


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