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AuthorKarin-Kujundzic, Valentina
AuthorSola, Ida Marija
AuthorPredavec, Nina
AuthorPotkonjak, Anamarija
AuthorSomen, Ema
AuthorMioc, Pavao
AuthorSerman, Alan
AuthorVranic, Semir
AuthorSerman, Ljiljana
Available date2019-11-24T07:04:39Z
Publication Date2019-11-18
Publication NameCellsen_US
Identifierhttp://dx.doi.org/10.3390/cells8111459
CitationKarin-Kujundzic, V.; Sola, I.M.; Predavec, N.; Potkonjak, A.; Somen, E.; Mioc, P.; Serman, A.; Vranic, S.; Serman, L. Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers. Cells 2019, 8, 1459.
ISSN2073-4409
URIhttp://hdl.handle.net/10576/12329
AbstractAs the majority of cancers and gestational diseases are prognostically stage- and grade-dependent, the ultimate goal of ongoing studies in precision medicine is to provide early and timely diagnosis of such disorders. These studies have enabled the development of various new diagnostic biomarkers, such as free circulating nucleic acids, and detection of their epigenetic changes. Recently, extracellular vesicles including exosomes, microvesicles, oncosomes, and apoptotic bodies have been recognized as powerful diagnostic tools. Extracellular vesicles carry specific proteins, lipids, DNAs, mRNAs, and miRNAs of the cells that produced them, thus reflecting the function of these cells. It is believed that exosomes, in particular, may be the optimal biomarkers of pathological pregnancies and cancers, especially those that are frequently diagnosed at an advanced stage, such as ovarian cancer. In the present review, we survey and critically appraise novel epigenetic biomarkers related to free circulating nucleic acids and extracellular vesicles, focusing especially on their status in trophoblasts (pregnancy) and neoplastic cells (cancers).
Languageen
PublisherMDPI
Subjectcell-free DNA
Subjectcell-free fetal DNA
Subjectcell-free tumor DNA
Subjectexosomes
Subjectextracellular vesicles
SubjectmicroRNA
TitleNovel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers
TypeArticle
Volume Number8
ESSN2073-4409


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