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AuthorCyprian, Farhan
AuthorLefkou, Eleftheria
AuthorVaroudi, Katerina
AuthorGirardi, Guillermina
Available date2019-12-23T08:51:09Z
Publication Date2019
Publication NameFrontiers in Immunologyen_US
Identifierhttp://dx.doi.org/10.3389/fimmu.2019.02739
CitationCyprian F, Lefkou E, Varoudi K and Girardi G (2019) Immunomodulatory Effects of Vitamin D in Pregnancy and Beyond. Front. Immunol. 10:2739. doi: 10.3389/fimmu.2019.02739
IdentifierArticle # 2739
URIhttp://hdl.handle.net/10576/12409
AbstractIn addition to its role in calcium homeostasis and bone formation, a modulatory role of the active form of vitamin D on cells of the immune system, particularly T lymphocytes, has been described. The effects of vitamin D on the production and action of several cytokines has been intensively investigated in recent years. In this connection, deficiency of vitamin D has been associated with several autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), Hashimoto Thyroiditis (HT), and multiple sclerosis (MS). In a successful pregnancy, the maternal immune response needs to adapt to accommodate the semiallogeneic fetus. Disturbances in maternal tolerance are implicated in infertility and pregnancy complications such as miscarriages (RM) and preeclampsia (PE). It is well-known that a subset of T lymphocytes, regulatory T cells (Tregs) exhibit potent suppressive activity, and have a crucial role in curtailing the destructive response of the immune system during pregnancy, and preventing autoimmune diseases. Interestingly, vitamin D deficiency is common in pregnant women, despite the widespread use of prenatal vitamins, and adverse pregnancy outcomes such as RM, PE, intrauterine growth restriction have been linked to hypovitaminosis D during pregnancy. Research has shown that autoimmune diseases have a significant prevalence within the female population, and women with autoimmune disorders are at higher risk for adverse pregnancy outcomes. Provocatively, dysregulation of T cells plays a crucial role in the pathogenesis of autoimmunity, and adverse pregnancy outcomes where these pathologies are also associated with vitamin D deficiency. This article reviews the immunomodulatory role of vitamin D in autoimmune diseases and pregnancy. In particular, we will describe the role of vitamin D from conception until delivery, including the health of the offspring. This review highlights an observational study where hypovitaminosis D was correlated with decreased fertility, increased disease activity, placental insufficiency, and preeclampsia in women with APS.
Languageen
PublisherFrontiers Media
Subjectantiphospholipid antibodies
Subjectautoimmunity
Subjectfetal origin of adult disease
Subjectplacenta
Subjectpregnancy
Subjectvitamin D
TitleImmunomodulatory Effects of Vitamin D in Pregnancy and Beyond.
TypeArticle
Volume Number10
dc.identifier.essn 1664-3224


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