Oxidation–reduction potential and sperm DNA fragmentation, and their associations with sperm morphological anomalies amongst fertile and infertile men
Al Said S.
El Ansari W.
Al Rumaihi K.
...show more authors ...show less authors
MetadataShow full item record
Objective: To assess seminal oxidation–reduction potential (ORP) and sperm DNA fragmentation (SDF) in male infertility and their relationships with sperm morphology in fertile and infertile men. Patients and methods: Prospective case-control study comparing the findings of infertile men (n = 1168) to those of men with confirmed fertility (n = 100) regarding demographics and semen characteristics (conventional and advanced semen tests). Spearman rank correlation assessed the correlation between ORP, SDF, and different morphological indices. Means of ORP and SDF were assessed in variable levels of normal sperm morphology amongst all participants. Results: Infertile patients had a significantly lower mean sperm count (32.7 vs 58.7 × 10 6 sperm/mL), total motility (50.1% vs 60.4%), and normal morphology (5.7% vs 9.9%). Conversely, infertile patients had significantly higher mean head defects (54% vs 48%), and higher ORP and SDF values than fertile controls. ORP and SDF showed significant positive correlations and significant negative correlations with sperm head defects and normal morphology in infertile patients, respectively. ORP and SDF were significantly inversely associated with the level of normal sperm morphology. Using receiver operating characteristic curve analysis, ORP and SDF threshold values of 1.73 mV/10 6 sperm/mL and 25.5%, respectively, were associated with 76% and 56% sensitivity and 72% and 72.2% specificity, respectively, in differentiating <4% from ≥4% normal morphology. Conclusion: A direct inverse relationship exists between seminal ORP and SDF with various levels of normal sperm morphology. Using ORP and SDF measures in conjunction with standard semen morphology analysis could validate the result of the fertility status of patients. © 2017 Arab Association of Urology
- Medicine Research [758 items ]
Showing items related by title, author, creator and subject.
Chromosomal abnormalities in infertile men with azoospermia and severe oligozoospermia in Qatar and their association with sperm retrieval intracytoplasmic sperm injection outcomes Arafa M.M.; Majzoub A.; AlSaid S.S.; ElAnsari W.; Al Ansari A.; Elbardisi Y.; Elbardisi H.T.... more authors ... less authors ( Arab Association of Urology , 2018 , Article)Objective: To study the types and incidence of chromosomal abnormalities in infertile men with azoospermia and severe oligozoospermia in Qatar, and to compare the hormonal changes, testicular sperm retrieval rate, and ...
SPERM FACTORS AND EGG ACTIVATION The structure and function relationship of sperm PLCZ1 Thanassoulas, Angelos; Swann, Karl; Lai, F. Anthony; Nomikos, Michail ( BioScientifica , 2022 , Article Review)In 2002, sperm-specific phospholipase C zeta1 (PLCZ1) was discovered and through these 20 years, it has been established as the predominant sperm oocyte-activating factor. PLCZ1 cRNA expression or direct protein microinjection ...
Karyotype, Meiosis And Sperm Formation In The Land Snail Macrochlamys Indica El Alfy, Nagla Z. [نجلاء زكي الالفي]; Abdel-Rehim, A. H.; Al-Ali, K. A. ( Qatar University , 1994 , Article)Karyotype analysis, meiosis and sperm formation of the land snail Macrochlamys indica collected from different farms of ornamental plants in Doha city of the State of Qatar were investigated. The chromosome number is n=24 ...