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المؤلفVinothini K.
المؤلفJeyaraj M.
المؤلفKumar S.K.
المؤلفRajan M.
تاريخ الإتاحة2020-03-18T10:47:18Z
تاريخ النشر2019
اسم المنشورChemistrySelect
المصدرScopus
الرقم المعياري الدولي للكتاب23656549
معرّف المصادر الموحدhttp://dx.doi.org/10.1002/slct.201803339
معرّف المصادر الموحدhttp://hdl.handle.net/10576/13464
الملخصIn this study, the paclitaxel (PTX) - loaded A?B type di-block polymeric micelles poly xylitol sebacate-poly methylmethacrylic acid/Lanthanum Oxide/paclitaxel (PXS-PMAA/LO/PTX) were designed and Lanthanum oxide nanoparticles were tagged on the surface of the micelle for the improvement of the antitumor drug efficiency in the cancer cells. LO nanoparticles influence the formation of sphere-shaped micelles and production of reactive oxygen species (ROS) to inhibite the cancer.Then, in-vitro drug release of PTX was carried out by UV-Vis spectroscopy and it was examined for pH depended drug releases. Cell uptake of the PTX-loaded micelles was investigated in human norml cell VERO and A549 cell line. The cytotoxicity study reveals that the PTX-loaded polymeric nano micelle has higher efficacy compared to free PTX. Living cell, cell apoptosis, ROS production and nuclear morphological changes were analyzed through Acridine Orange/Ethidium Bromide dual stain, cationic probe rhodamine 123, 2,7-dichlorofluorescene and Hoechst 33342 staining respectively. Hence, the PTX-loaded PXS-PMAA/LO carrier can act as potential drug carrier for cancer treatment.
اللغةen
الناشرWiley-Blackwell
الموضوعCytotoxicity
Di-block copolymer
Lanthanum Oxide
Paclitaxel
pH-responsive Drug Delivery
العنوانDual Role of Lanthanum Oxide Nanoparticles Functionalized Co-Polymeric Micelle for Extended Anti-Cancer Drug Delivery
النوعArticle
الصفحات5206-5213
رقم العدد18
رقم المجلد4
dc.accessType Abstract Only


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