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AuthorVinothini K.
AuthorJeyaraj M.
AuthorKumar S.K.
AuthorRajan M.
Available date2020-03-18T10:47:18Z
Publication Date2019
Publication NameChemistrySelect
ResourceScopus
ISSN23656549
URIhttp://dx.doi.org/10.1002/slct.201803339
URIhttp://hdl.handle.net/10576/13464
AbstractIn this study, the paclitaxel (PTX) - loaded A?B type di-block polymeric micelles poly xylitol sebacate-poly methylmethacrylic acid/Lanthanum Oxide/paclitaxel (PXS-PMAA/LO/PTX) were designed and Lanthanum oxide nanoparticles were tagged on the surface of the micelle for the improvement of the antitumor drug efficiency in the cancer cells. LO nanoparticles influence the formation of sphere-shaped micelles and production of reactive oxygen species (ROS) to inhibite the cancer.Then, in-vitro drug release of PTX was carried out by UV-Vis spectroscopy and it was examined for pH depended drug releases. Cell uptake of the PTX-loaded micelles was investigated in human norml cell VERO and A549 cell line. The cytotoxicity study reveals that the PTX-loaded polymeric nano micelle has higher efficacy compared to free PTX. Living cell, cell apoptosis, ROS production and nuclear morphological changes were analyzed through Acridine Orange/Ethidium Bromide dual stain, cationic probe rhodamine 123, 2,7-dichlorofluorescene and Hoechst 33342 staining respectively. Hence, the PTX-loaded PXS-PMAA/LO carrier can act as potential drug carrier for cancer treatment.
Languageen
PublisherWiley-Blackwell
SubjectCytotoxicity
Di-block copolymer
Lanthanum Oxide
Paclitaxel
pH-responsive Drug Delivery
TitleDual Role of Lanthanum Oxide Nanoparticles Functionalized Co-Polymeric Micelle for Extended Anti-Cancer Drug Delivery
TypeArticle
Pagination5206-5213
Issue Number18
Volume Number4
dc.accessType Abstract Only


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