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AuthorAlhmoud, Jehad F
AuthorWoolley, John F
AuthorAl Moustafa, Ala-Eddin
AuthorMalki, Mohammed Imad
Available date2020-04-26T06:05:12Z
Publication Date2020-04-23
Publication NameCancers
Identifierhttp://dx.doi.org/10.3390/cancers12041050
CitationAlhmoud, J.F.; Woolley, J.F.; Moustafa, A.-E.A.; Malki, M.I. DNA Damage/Repair Management in Cancers. Cancers 2020, 12, 1050.
ISSN2072-6694
URIhttp://hdl.handle.net/10576/14494
AbstractDNA damage is well recognized as a critical factor in cancer development and progression. DNA lesions create an abnormal nucleotide or nucleotide fragment, causing a break in one or both chains of the DNA strand. When DNA damage occurs, the possibility of generated mutations increases. Genomic instability is one of the most important factors that lead to cancer development. DNA repair pathways perform the essential role of correcting the DNA lesions that occur from DNA damaging agents or carcinogens, thus maintaining genomic stability. Inefficient DNA repair is a critical driving force behind cancer establishment, progression and evolution. A thorough understanding of DNA repair mechanisms in cancer will allow for better therapeutic intervention. In this review we will discuss the relationship between DNA damage/repair mechanisms and cancer, and how we can target these pathways.
SponsorQatar University: QUCG‐CMED‐20/21‐3, QUST‐1‐CMED‐2019‐23 and QUST‐1‐CMED‐2020‐13.
Languageen
PublisherMDPI
Relationhttp://hdl.handle.net/10576/25103
SubjectDNA damage
DNA repair pathway
DNA lesion
Genomic instability
TitleDNA Damage/Repair Management in Cancers
TypeArticle Review
Issue Number4
Volume Number12
dc.accessType Open Access


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