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    Investigation of antimicrobial properties and in-vitro bioactivity of Ce3+-Sr2+dual-substituted nano hydroxyapatites

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    Date
    2019
    Author
    Sundarabharathi, Lakshmanaperumal
    Chinnaswamy, Mahendran
    Ponnamma, Deepalekshmi
    Parangusan, Hemalatha
    Al-Maadeed, Mariam Al Ali
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    Abstract
    Dual doped calcium apatite has been widely focused as it enhances the osteoconductive property for the possible applications in orthopedic and dental implants. In this work, we investigate the antimicrobial and bioactive properties of cerium/strontium (Ce3+/Sr2+) co‐substituted hydroxyapatite (HA ) nanoparticles synthesized by sol‐gel assisted precipitation method. The structure, morphology, functional groups, photoluminescence, and thermal stability of the developed systems are examined. The comparative studies performed among the pure HA , Sr2+, and Ce3+‐substituted HA nanoparticles illustrate higher antibacterial activity with lowered apatite‐forming ability and biocompatibility for the Ce3+‐substituted HA . However, the Ce3+/Sr2+co‐substituted HA exhibits better biocompatibility, apatite‐forming ability, and good antimicrobial properties. Sr2+ ion inclusion leads to better biological properties and compromise the cytotoxic nature of the Ce3+‐HA . In addition, the Ce3+/Sr2+‐HA nanoparticles prevent thermal decomposition up to 700°C, pointing also toward the possibility of this co‐substituted HA in bone implant applications.
    DOI/handle
    http://dx.doi.org/10.1111/jace.15866
    http://hdl.handle.net/10576/15127
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    • Center for Advanced Materials Research [‎1505‎ items ]
    • Materials Science & Technology [‎316‎ items ]

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