Show simple item record

AuthorMousa, Hanaa
AuthorElgamal, Mahmoud
AuthorMarei, Reham Ghazal
AuthorSouchelnytskyi, Nazariy
AuthorLin, Kah-Wan.
AuthorSouchelnytskyi, Serhiy
Available date2020-08-18T08:34:16Z
Publication Date2019
Publication NameCancer Genomics and Proteomics
ResourceScopus
ISSN11096535
URIhttp://dx.doi.org/10.21873/CGP.20153
URIhttp://hdl.handle.net/10576/15576
AbstractBackground/Aim: Proteomics of invasiveness opens a window on the complexity of the metastasis-engaged mechanisms. The extend and types of this complexity require elucidation. Materials and Methods: Proteomics, immuno -histochemistry, immunoblotting, network analysis and systems cancer biology were used to analyse acquisition of invasiveness by human breast adenocarcinoma cells. Results: We report here that invasiveness network highlighted the involvement of hallmarks such as cell proliferation, migration, cell death, genome stability, immune system regulation and metabolism. Identified involvement of cell-virus interaction and gene silencing are potentially novel cancer mechanisms. Identified 6,113 nodes with 11,055 edges affecting 1,085 biological processes show extensive re-arrangements in cell physiology. These high numbers are in line with a similar broadness of networks built with diagnostic signatures approved for clinical use. Conclusion: Our data emphasize a broad systemic regulation of invasiveness, and describe the network of this regulation. - 2019 International Institute of Anticancer Research. All rights reserved.
Languageen
PublisherInternational Institute of Anticancer Research
SubjectBreast cancer
Invasiveness
Proteomics
Systems biology
TitleAcquisition of invasiveness by breast adenocarcinoma cells engages established hallmarks and novel regulatory mechanisms
TypeArticle
Pagination505-518
Issue Number6
Volume Number16
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record